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EC number: 253-326-2 | CAS number: 37052-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 April 1978 - 10 April 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- other: organ toxicity
Test material
- Reference substance name:
- 1,3-dihydro-5-methoxy-2H-benzimidazole-2-thione
- EC Number:
- 253-326-2
- EC Name:
- 1,3-dihydro-5-methoxy-2H-benzimidazole-2-thione
- Cas Number:
- 37052-78-1
- Molecular formula:
- C8H8N2OS
- IUPAC Name:
- 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione
Constituent 1
- Specific details on test material used for the study:
- Batch numer 70620
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The rats were during the trial housed 6 to a cage with free access to food and water. The temperature in the animal room was + 21°C
± 1°C and the relative humidity was 55-60 %.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.7 % w/v Methocel®
- Details on exposure:
- The suspended test compounds were administered orally by use of a gastric tube. The desired dose was given in a volume of 10 ml/kg body mass. The animals were dosed on two separate occasions, between which there was an interval of 5 days
- Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- The animals were dosed on two separate occasions, between which there was an interval of 5 days
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, concurrent vehicle
Examinations
- Examinations:
- Clinical observations:
Food consumption was recorded at the end of the five day period, and the mean daily consumption per rat was calculated.
Body masses were recorded at the beginning and end of the trial.
Iodide uptake in the thyroid:
One hour after the second occasion of drug administration and 4 hours before sacrifice 178 kBq 125I- in 0.50 ml NaCl (155 mmol/1) was injected intraperitoneally into all the rats. The thyroid glands were placed in vials for gamma counting.
Pathology:
The thymus glands were weighed. No histologic investigation was carried out.
Results and discussion
- Details on results:
- Food consumption: There was no marked difference in food consumption between the treated and control animals.
Body weight: There was no marked difference between the treated rats and control rats.
Iodide uptake in the thyroid: The amount of radioactivity in the thyroids of treated and control animals, expressed as ratio of the group mean values (treated to controls) and as depression of iodide uptake. There was 93% depression of the iodide uptake in the group treated with metmercazole.
Pathology, Thymus masses: The substance evoked a significant decrease of the thymus mass in the rats.The relative thymus weight was significantly lower in the metmercazole group compared to control (61% of control).
Applicant's summary and conclusion
- Conclusions:
- Expsure to Metmercazol effects the thymus.
Classification: Specific target organ toxicity, single exposure, category 1. Target organ: Thymus - Executive summary:
The effect of metmercazole on the thymus have been investigated. Metmercazole was given orally using a dose of 72mg/kg. The animals were dosed on two separate occasions with 5 days in between. The last dose was given 5 hours before termination. Thymus weight and iodine uptake in the thymus was measured. Not histological examination of the thymuses was carried out. Exposure to metmercazole significantly decreased the iodine uptake (93% reduction). The relative thymus weight was significantly lower in the metmercazole group compared to control (61% of control).Target organ is the thymus based on the clear effect on weight and the supporting information regard the reduced iodine uptake in the thymus. The mechanism behind the reduced iodine uptake and reduced thymus weight is unknown.
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