Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to birds

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to birds: reproduction test
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
C12 LAS; Linear Alkylbenzene Sulfonate (LAS)) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.
Reason / purpose for cross-reference:
read-across source
Qualifier:
no guideline followed
Principles of method if other than guideline:
Ten month old Leghorn chicken hens were given a dosage of 200 mg/kg in drinking water for 45 days. Four groups of six hens were used in the treatment group, with an additional six hens used as a control group.
GLP compliance:
no
Dose method:
drinking water
Analytical monitoring:
not specified
Vehicle:
yes
Test organisms (species):
other: Chicken (Leghorn hens)
Details on test organisms:
Chicken (Leghorn hens)
Limit test:
no
Total exposure duration (if not single dose):
45 d
No. of animals per sex per dose and/or stage:
Four groups of six hens were used in the treatment group, with an additional six hens used as a control group.
Control animals:
yes
Nominal and measured doses / concentrations:
Ten month old Leghorn chicken hens were given a dosage of 200 mg/kg in drinking water for 45 days
Reference substance (positive control):
not specified
Duration (if not single dose):
45 d
Dose descriptor:
NOEC
Effect level:
200 mg/kg diet
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Remarks:
egg quality
Duration (if not single dose):
45 d
Dose descriptor:
NOEL
Effect level:
25 mg/kg bw/day
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Remarks:
egg quality

While this is a non-standard study, it does indicate that up to 200 mg/kg in the drinking water does not adversely affect hens or egg laying

Validity criteria fulfilled:
yes
Conclusions:
NOEC = 200 mg/kg diet
Based on the study No mortality or adverse effects on egg quality occurred at 200 mg/kg.

Description of key information

For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
The NOELs can be converted to NOECs with the following two formulae:
 
NOECbird=NOELbird.CONVbird
 
Conversion factors from NOEL to NOEC for bird species Leghorn hens is 8(bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
 
NOECbird=25x 8=200mg/kg/diet
 
 
NOEC = 200 mg/kg diet
Based on the study of Lopez-Zavalla, A.,et al 1975, No mortality or adverse effects on egg quality occurred at 200 mg/kg.
 

Key value for chemical safety assessment

Short-term EC50 or LC50 for birds:
1 000 mg/kg food
Long-term EC10, LC10 or NOEC for birds:
200 mg/kg food

Additional information

For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.

The NOELs can be converted to NOECs with the following two formulae:

 

NOECbird=NOELbird.CONVbird

 

Conversion factors from NOEL to NOEC for bird species Leghorn hens is 8(bw/dfi)

bw = body weight (g); dfi: daily food intake (g/day)

 

NOECbird=25x 8=200mg/kg/diet

 

 

NOEC = 200 mg/kg diet

Based on the study of Lopez-Zavalla, A.,et al 1975, No mortality or adverse effects on egg quality occurred at 200 mg/kg.

 

Categories Display