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EC number: 247-557-8 | CAS number: 26264-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- C12 LAS; Linear Alkylbenzene Sulfonate (LAS)) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Study type:
- cross sectional study
- Endpoint addressed:
- skin irritation / corrosion
- skin sensitisation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method:In a review of 1 581 540 cases of human exposure to a wide range of chemicals reported by the United States Poison Control Centers in 1989, 7983 people had been exposed to household automatic dishwasher preparations (alkali, anionic or nonionic, other or unknown) and 506 had required treatment in a health facility; 8950 had been exposed to household cleansers, with 894 requiring treatment; 12 876 had been exposed to laundry preparations, with 1542 treated; and 621 had been exposed to industrial detergents (anionic, cationic, nonionic), with 321 cases requiring treatment.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- C12-LAS
- IUPAC Name:
- C12-LAS
- Details on test material:
- C12-LAS
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- no
- Details on study design:
- In a review of 1 581 540 cases of human exposure to a wide range of chemicals reported by the United States Poison Control Centers in 1989, 7983 people had been exposed to household automatic dishwasher preparations (alkali, anionic or nonionic, other or unknown) and 506 had required treatment in a health facility; 8950 had been exposed to household cleansers, with 894 requiring treatment; 12 876 had been exposed to laundry preparations, with 1542 treated; and 621 had been exposed to industrial detergents (anionic, cationic, nonionic), with 321 cases requiring treatment.
- Exposure assessment:
- estimated
Results and discussion
- Results:
- There were no deaths, and only 12 of the treated cases were classified as 'major outcome'. Virtually all the reports involved accidental exposure. The compositions of the cleaning preparations, routes of exposure, and clinical descriptions were not provided
Applicant's summary and conclusion
- Conclusions:
- There were no deaths, and only 12 of the treated cases were classified as 'major outcome'. Virtually all the reports involved accidental exposure. The compositions of the cleaning preparations, routes of exposure, and clinical descriptions were not provided
- Executive summary:
EFFECTS ON HUMANS
Summary
Human skin can tolerate contact with solutions of up to 1% LAS for 24 h with only mild irritation. Like other surfactants, LAS can deliapidate the skin surface, elute natural moisturizing factor, denature the proteins of the outer epidermal layer, and increase permeability and swelling of the outer layer. LAS do not induce skin sensitization in humans, and there is no conclusive evidence that they induce eczema. No serious injuries or fatalities have been reported following accidental ingestion of LAS-containing surfactant preparations.
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