Calcium dodecylbenzenesulphonate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method: other:Test material was applied to shaved area of back of 6 rabbits at two doses: 2000 mg/kg (undiluted) and 212 mg/kg (2% aqueous dilution). The areas were covered with plastic and left in contact with test material for 24 hours.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzenesulfonic acid, C10-16-alkyl derivs.

EC Number:

271-528-9

EC Name:

Benzenesulfonic acid, C10-16-alkyl derivs.

Cas Number:

68584-22-5

IUPAC Name:

4-dodecylbenzenesulfonic acid

Test material form:

other: liquid

Details on test material:

- Name of test material (as cited in study report):Benzene sulfonic acid, C10-16-alkyl derivatives (68584-22-5)

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Test material was applied to shaved area of back of 6 rabbits at two doses: 2000 mg/kg (undiluted) and 212 mg/kg (2% aqueous dilution). The areas were covered with plastic and left in contact with test material for 24 hours.

Duration of exposure:

24 hr

Doses:

2000 mg/kg (undiluted) and 212 mg/kg bw (2% aqueous dilution)

No. of animals per sex per dose:

6

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Remarks:

undiluted

Effect levels 2

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 212 mg/kg bw

Based on:

test mat.

Remarks:

(2% aqueous dilution)

Mortality:

All of the animals exposed to the 212 mg/kg survived.
Mortality occurred in three out of six rabbits exposed to the undiluted dose.
LD50 = 2000 mg/kg bw (undiluted); LD50 > 212 mg/kg bw (2% aqueous dilution)

Clinical signs:

other: Local skin reactions included erythema, mild edema and mild desquamation at 212 mg/kg and chemical burns, severe edema and necrosis at 2000 mg/kg. No untoward behavioral reactions were observed.

Gross pathology:

Necropsy did not reveal any gross pathological alterations.

Applicant's summary and conclusion

Interpretation of results:

other: not classified

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The acute lethal dermal dose was found to be 2000 mg/kg (undiluted) and LD50 > 212 mg/kg bw (2% aqueous dilution)

Executive summary:

The acute lethal dermal dose was found to be 2000 mg/kg (undiluted) and LD50 > 212 mg/kg bw (2% aqueous dilution)