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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: other:Test material was applied to shaved area of back of 6 rabbits at two doses: 2000 mg/kg (undiluted) and 212 mg/kg (2% aqueous dilution). The areas were covered with plastic and left in contact with test material for 24 hours.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Benzenesulfonic acid, C10-16-alkyl derivs.
EC Number:
271-528-9
EC Name:
Benzenesulfonic acid, C10-16-alkyl derivs.
Cas Number:
68584-22-5
IUPAC Name:
4-dodecylbenzenesulfonic acid
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report):Benzene sulfonic acid, C10-16-alkyl derivatives (68584-22-5)

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Test material was applied to shaved area of back of 6 rabbits at two doses: 2000 mg/kg (undiluted) and 212 mg/kg (2% aqueous dilution). The areas were covered with plastic and left in contact with test material for 24 hours.
Duration of exposure:
24 hr
Doses:
2000 mg/kg (undiluted) and 212 mg/kg bw (2% aqueous dilution)
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 000 mg/kg bw
Based on:
test mat.
Remarks:
undiluted
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 212 mg/kg bw
Based on:
test mat.
Remarks:
(2% aqueous dilution)
Mortality:
All of the animals exposed to the 212 mg/kg survived.
Mortality occurred in three out of six rabbits exposed to the undiluted dose.
LD50 = 2000 mg/kg bw (undiluted); LD50 > 212 mg/kg bw (2% aqueous dilution)
Clinical signs:
Local skin reactions included erythema, mild edema and mild desquamation at 212 mg/kg and chemical burns, severe edema and necrosis at 2000 mg/kg. No untoward behavioral reactions were observed.
Gross pathology:
Necropsy did not reveal any gross pathological alterations.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The acute lethal dermal dose was found to be 2000 mg/kg (undiluted) and LD50 > 212 mg/kg bw (2% aqueous dilution)
Executive summary:

The acute lethal dermal dose was found to be 2000 mg/kg (undiluted) and LD50 > 212 mg/kg bw (2% aqueous dilution)

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