Registration Dossier
Registration Dossier
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EC number: 247-557-8 | CAS number: 26264-06-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- MSDS RHODOCAL®CA/70
- Author:
- Rhodia
- Year:
- 1 998
- Bibliographic source:
- Product Safety Labs
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Calcium dodecylbenzenesulphonate
- EC Number:
- 247-557-8
- EC Name:
- Calcium dodecylbenzenesulphonate
- Cas Number:
- 26264-06-2
- Molecular formula:
- C36H58CaO6S2
- IUPAC Name:
- calcium bis(2-undecylbenzene-1-sulfonate)
- Details on test material:
- (Benzenesulfonic acid, dodecyl-,calcium salt), purity 69-71%.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 24 hrs
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hrs
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- > 1 - < 3
- Remarks on result:
- other: May cause serious damage to eyes
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The test substance is classified as R41, may cause serious damage to eyes, under the DSD.
- Executive summary:
Rabbits were exposed to 0.1 ml of 100% test substance in the eye for 24 hrs. Results show that the test substance may cause serious damage to the eyes.
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