Registration Dossier
Registration Dossier
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EC number: 928-136-4 | CAS number: 92128-67-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given:comparable to guidelines/standards.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Noakes, DN, and Sanderson, DM (1969). A method for determining the dermal toxicity of pesticides. Br. J. Industr. Med., 26, 59-64.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)
- EC Number:
- 919-446-0
- IUPAC Name:
- Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd, Manston, Kent
Administration / exposure
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1, 2, or 4 ml/kg - Duration of exposure:
- 24 hrs
- Doses:
- 1, 2, 4 ml/kg
- No. of animals per sex per dose:
- 2 animals of each sex per dose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 mL/kg bw
- Mortality:
- No animals died during the study.
Any other information on results incl. tables
Mortality
Dose ml/kg |
Males |
Female |
Total |
1 |
0/2 |
0/2 |
0/4 |
2 |
0/2 |
0/2 |
0/4 |
4 |
0/2 |
0/2 |
0/4 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The dermal LD50 for rats is > 4 ml/kg (~3400 mg/ kg bw).
- Executive summary:
This study examined the acute toxicity of Dilutine M5 to rats via dermal exposure. 2 female and 2 male rats were exposed to 1, 2, or 4 ml/kg of undiluted test material dermally for 24 hrs. No rats died during the experiment. The dermal LD50 for rats is > 4 ml/kg (~3400mg/kg bw).
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