Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vitro
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(1H-indol-3yl)ethanamine
EC Number:
692-120-0
Cas Number:
124955-50-6
Molecular formula:
C10H12N2*H3PO4
IUPAC Name:
2-(1H-indol-3yl)ethanamine
Test material form:
solid: crystalline
Details on test material:
Test item: tryptamine phosphateCAS No.:124955-50-6Batch No.: S62233NPhysical state: brown or beige crystalline powderStorage: 8-15 °C, protected from light and wet

Results and discussion

Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)

Any other information on results incl. tables

Software Database / Method Species Predicted value
Toxtree In vitro mutagenicity (Ames test) alerts by ISS Structural alerts No alerts indentified
ChemProp Mutagenicity by Kazius et al. Structural alerts Not active

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: Toxtree, ChemProp, the predicted values indicated that tryptamine phosphate is not mutagen.