Registration Dossier
Registration Dossier
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EC number: 241-379-4 | CAS number: 17354-14-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early study, no GLP, short report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- pre-dates GLP regulation
Test material
- Reference substance name:
- 1,4-bis(butylamino)anthraquinone
- EC Number:
- 241-379-4
- EC Name:
- 1,4-bis(butylamino)anthraquinone
- Cas Number:
- 17354-14-2
- Molecular formula:
- C22H26N2O2
- IUPAC Name:
- 1,4-bis(butylamino)anthraquinone
- Details on test material:
- technically pure
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: white Wiener
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BASF
- Age at study initiation: no data
- Weight at study initiation: 2,3 kg (mean)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1 - 2 g/ animal
- Concentration (suspesion): 50 % - Duration of treatment / exposure:
- 20 h
- Observation period:
- 8 days
- Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: 6,25 cm²
- Type of wrap if used: semi-occlusve
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
Results and discussion
In vivo
Results
- Irritation parameter:
- other: No numbers were given
- Remarks on result:
- other: In 3 of 4 animals very slight to slight reddening was observed
- Irritant / corrosive response data:
- In 3 of 4 animals very slight to slight, transient reddening was observed 24 h after treatment
- Other effects:
- Blue discoloration by the substance
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material not irritant after semi-occlusive treatment of rabbit skin for 20 hours.
- Executive summary:
The skin irritation hazard was tested in rabbits by semi-occlusive application of the test material for 20 hours. Animals were treated with a 50% aqueous paste. Observations werer made after 1, 5 oand 15 minutes of contact to the skin. Afterwards animals were treated for 20 hours.
After application for short periods the skin was without any finding. Application for 20 hours caused very slight to slight reddening of the treated areas in 3 of 4 rabbits. Additionally the skin was blue discolored by the test material.
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