Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-379-4 | CAS number: 17354-14-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early study, no GLP, short report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- pre-dates GLP regulation
Test material
- Reference substance name:
- 1,4-bis(butylamino)anthraquinone
- EC Number:
- 241-379-4
- EC Name:
- 1,4-bis(butylamino)anthraquinone
- Cas Number:
- 17354-14-2
- Molecular formula:
- C22H26N2O2
- IUPAC Name:
- 1,4-bis(butylamino)anthraquinone
- Details on test material:
- technically pure
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: White Wiener
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: BASF
- Weight at study initiation: ca. 2,3 kg ( mean)
- Diet (e.g. ad libitum):ad libitum
- Water (e.g. ad libitum): ad libitum
Test system
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- ca 50 mg
50% paste - Duration of treatment / exposure:
- not limitd (no washing)
- Observation period (in vivo):
- 8 days.
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
no
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: all
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: verbal report, no numbers given
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: all
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: verbal report, no numbers given
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 and 24 h
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: slight reddening was reported, no number given
- Irritant / corrosive response data:
- Slight reddening of the conjunctivae was observed at 1 and 24 Hours after treatment.
- Other effects:
- no other effects occurred.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was not irritant or corrosive on the eyes of two rabbits.
- Executive summary:
Application of 50 mg/ animal on one eye of each rabbit caused only slight reddening of the conjunctivae after 1 and 24 hours. No systemic effects occurred. The material was not irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
