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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (Acute Toxic Class Method).
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
444-140-4
EC Name:
-
Cas Number:
18934-00-4
Molecular formula:
C12H22O3
IUPAC Name:
3-ethyl-3-{[(3-ethyloxetan-3-yl)methoxy]methyl}oxetane
Test material form:
liquid

Test animals

Species:
other: Rat (Sprague-Dawley)

Administration / exposure

Vehicle:
arachis oil

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
< 2 000 mg/kg bw
Mortality:
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 3
Female: 300 mg/kg bw; Number of animals: 3; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Signs of systemic toxicity noted in animals treated at a
dose level of 2000 mg/kg were hunched posture, decreased
respiratory rate, laboured and/or noisy respiration,
occasional body tremors and coma.
Four animals treated at a dose level of 2000 mg/kg were
found dead during the day of dosing.
No signs of systemic toxicity were noted in animals treated
at a dose level of 300 mg/kg.
Gross pathology:
Effects on organs:
Abnormalities noted at necropsy of animals that died during
the study were dark liver, pale liquid present in the
stomach and sloughing of the non-glandular region of the
stomach.
No abnormalities were noted at necropsy of animals killed at
the end of the study period.

Applicant's summary and conclusion

Interpretation of results:
other: harmful