Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
444-140-4
EC Name:
-
Cas Number:
18934-00-4
Molecular formula:
C12H22O3
IUPAC Name:
3-ethyl-3-{[(3-ethyloxetan-3-yl)methoxy]methyl}oxetane
Test material form:
liquid
Specific details on test material used for the study:
Physical form of substance: L
Mass median aerodynamic diameter (for liq.+solid aerosol):
3.21 μm

Test animals

Species:
other: Sprague-Dawley CD

Administration / exposure

Vehicle:
other: none
Details on inhalation exposure:
Aerosol atmosphere

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 4.78 mg/L air
Mortality:
Male: 4.78 mg/L; Number of animals: 5; Number of deaths: 0
Female: 4.78 mg/L; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: There were no deaths during the study. Common abnormalities noted during the study included increased respiratory rate, haunched posture, pilo-erection and wet fur. All animals recovered quickly to appear normal f
Gross pathology:
Effects on organs:
No macroscopic abnormalities were detected at necropsy.

Applicant's summary and conclusion

Interpretation of results:
other: not classified