Registration Dossier
Registration Dossier
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EC number: 444-140-4 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Ames).
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 444-140-4
- EC Name:
- -
- Cas Number:
- 18934-00-4
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 3-ethyl-3-{[(3-ethyloxetan-3-yl)methoxy]methyl}oxetane
- Test material form:
- liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium: TA1535, TA1537, TA98 and TA100. Escherichia coli WP2 uvrA
- Metabolic activation system:
- Phenobarbital and 5,6-benzoflavone induced, rat-liver S9.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 156 ... 5000 μg/plate
Concentration range in the main test (without metabolic activation): 156 ... 5000 μg/plate - Vehicle / solvent:
- Solvent: Dimethyl sulfoxide
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with and without
- Genotoxicity:
- not specified
- Remarks:
- NA
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 5000 μg/plate
- Species / strain:
- other: as specified above
- Metabolic activation:
- with and without
- Genotoxicity:
- not specified
- Remarks:
- NA
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- 2500 μg/plate
Applicant's summary and conclusion
- Conclusions:
- negative with metabolic activation
negative without metabolic activation
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