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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only the study results were provided, no study plan, no dosage information, references or further details and it dates back to 1967

Data source

Reference
Reference Type:
grey literature
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Limited data are available; however the methodology appears to be broadly comparable to standard methods (e.g. OECD 401)
GLP compliance:
no
Remarks:
study pre-dates GLP introduction
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Linalyl propionate
EC Number:
205-627-5
EC Name:
Linalyl propionate
Cas Number:
144-39-8
Molecular formula:
C13H22O2
IUPAC Name:
linalyl propionate
impurity 1
Reference substance name:
Unknown impurities
Molecular formula:
not applicable
IUPAC Name:
Unknown impurities
Test material form:
liquid

Test animals

Species:
mouse
Strain:
other: CF-1
Sex:
male/female
Details on test animals or test system and environmental conditions:
CF-1 mice of both sexes weighing 17-25 grams. Ten mice were used per dose level.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
No information available
Doses:
No information available
No. of animals per sex per dose:
Ten mice were used per dose level
Control animals:
not specified
Details on study design:
CF-1 mice of both sexes weighing 17-25 grams were orally administered the compound, Ten mice were used per dose level, and the dosed animals were observed over 72 hours for mortality. LD50 values were calculated by the method of Miller and Tainter (Proc. Soc. Exptl. Biol. 57:261,1944)
Statistics:
Not reported

Results and discussion

Preliminary study:
No information available
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
13 874 mg/kg bw
Based on:
test mat.
Mortality:
Not reported
Clinical signs:
Not reported
Body weight:
Not reported
Gross pathology:
Not reported
Other findings:
Not reported

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test material is stated to be relatively non-toxic. No conclusion on classification can be made based on the results presented.
Executive summary:

CF-1 mice of both sexes weighing 17-25 grams were orally administered the compound, Ten mice were used per dose level, and the dosed animals were observed over 72 hours for mortality. The test material is stated to be relatively non-toxic LD 13,874 mg/kg; however further details are not reported.