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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17/7/1987 to 31/7/1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted to the OECD/EU guidelines in place at the time. It was also subject to QA however not under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(4-methylphenylthio)benzophenone
EC Number:
281-064-9
EC Name:
4-(4-methylphenylthio)benzophenone
Cas Number:
83846-85-9
Molecular formula:
C20H16OS
IUPAC Name:
{4-[(4-methylphenyl)sulfanyl]phenyl}(phenyl)methanone
Test material form:
solid: crystalline

Test animals

Species:
rat
Strain:
other: Cr1:COBS CD (SD) BR
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 20% w/v
- Amount of vehicle (if gavage): 10 ml/kg

Doses:
2000 mg/kg
No. of animals per sex per dose:
5 males and 5 females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were observed twice per day and weighed on days 1, 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic post-mortem examination
Statistics:
None performed

Results and discussion

Preliminary study:
Not applicable
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
There were no deaths.
Clinical signs:
Signs of reaction to treatment observed in all rats shortly after dosing were pilo-erection, abnormal body carriage (hunched posture) and abnormal gait (waddling). Recovery from signs was advanced by Day 2 and complete by Day 3.
Body weight:
Slightly low bodyweight gains were recorded for all females on Day 8 and for one female on Day 15.
Gross pathology:
There were no adverse findings

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 to rats by the oral route is >2000 mg/kg