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EC number: 210-734-5 | CAS number: 622-40-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicological Evaluation of Hydroxyethylmorpholine
- Author:
- Papciak, R.J. and Mallory, V.T.
- Year:
- 1 990
- Bibliographic source:
- Journal of the American College of Toxicity
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Probably no
Test material
- Reference substance name:
- 2-morpholinoethanol
- EC Number:
- 210-734-5
- EC Name:
- 2-morpholinoethanol
- Cas Number:
- 622-40-2
- Molecular formula:
- C6H13NO2
- IUPAC Name:
- 2-morpholinoethanol
- Reference substance name:
- O(CCN(C1)CCO)C1
- IUPAC Name:
- O(CCN(C1)CCO)C1
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Details on study design:
- Protocol: Test article (0.1 ml) was administrated directly to one eye of 6 young adult New Zealand White rabbits, weighing 2 to 3 kg. Ocular scoring of corneal, irridial, and conjuctival lesions with calculations of an ocular irritation score according to Draize et al. (1944). Study duration was 7 days.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 5.2
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Draize ocular irritation score = 5.2 of 110 @ 24 hours post treatment ; considered minimally irritating. Slight ocular irritation was observed through 72 hours. All scores returned to normal by day 7.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The intermediate substance is not classified with regards to Eye irritation according to CLP Criteria
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