Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-734-5 | CAS number: 622-40-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicological Evaluation of Hydroxyethylmorpholine
- Author:
- Papciak, R.J. and Mallory, V.T.
- Year:
- 1 990
- Bibliographic source:
- Journal of the American College of Toxicity
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Probably no
Test material
- Reference substance name:
- 2-morpholinoethanol
- EC Number:
- 210-734-5
- EC Name:
- 2-morpholinoethanol
- Cas Number:
- 622-40-2
- Molecular formula:
- C6H13NO2
- IUPAC Name:
- 2-morpholinoethanol
- Reference substance name:
- O(CCN(C1)CCO)C1
- IUPAC Name:
- O(CCN(C1)CCO)C1
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Details on study design:
- Protocol: Test article (0.1 ml) was administrated directly to one eye of 6 young adult New Zealand White rabbits, weighing 2 to 3 kg. Ocular scoring of corneal, irridial, and conjuctival lesions with calculations of an ocular irritation score according to Draize et al. (1944). Study duration was 7 days.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 5.2
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Draize ocular irritation score = 5.2 of 110 @ 24 hours post treatment ; considered minimally irritating. Slight ocular irritation was observed through 72 hours. All scores returned to normal by day 7.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The intermediate substance is not classified with regards to Eye irritation according to CLP Criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
