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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicological Evaluation of Hydroxyethylmorpholine
Author:
Papciak, R.J. and Mallory, V.T.
Year:
1990
Bibliographic source:
Journal of the American College of Toxicity

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
Probably no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-morpholinoethanol
Constituent 2
Reference substance name:
O(CCN(C1)CCO)C1
IUPAC Name:
O(CCN(C1)CCO)C1

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Details on study design:
Protocol: Test article (0.1 ml) was administrated directly to one eye of 6 young adult New Zealand White rabbits, weighing 2 to 3 kg. Ocular scoring of corneal, irridial, and conjuctival lesions with calculations of an ocular irritation score according to Draize et al. (1944). Study duration was 7 days.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
5.2
Reversibility:
fully reversible within: 7 days
Irritant / corrosive response data:
Draize ocular irritation score = 5.2 of 110 @ 24 hours post treatment ; considered minimally irritating. Slight ocular irritation was observed through 72 hours. All scores returned to normal by day 7.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The intermediate substance is not classified with regards to Eye irritation according to CLP Criteria