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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Description of key information

The log POW of the peak of test item PPDA was calculated as -0.250 ± 0.002 (mean ± standard deviation).

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
25 °C

Additional information

The study was performed using a HPLC with a C18 column.Sixreference items with different retention times and thiourea for the determination of the dead time were used to produce a calibration curve, since retention time on hydrophobic columns and POWare correlated. The reference items were chosen on behalf of the pre-test.

One vial was filled with the reference item mix and one vial with the test item solution. The vials were analysed using the HPLC with the program described. First one injection from the solvent blank methanol/water 65/35 (v/v) was made. Then three injections were measured from the reference item mix, three injections from the test item and again three injections from the reference item mix. For each reference item, the capacity factor K was calculated from the retention time of thiourea and the retention time of the respective reference item.

A calibration function (log K versus log POW, linear fit) was determined using the literature values for POWof the reference items and the retention times in the six determinations. 

The chromatogram of the test item gave one peak. With the calibration function log K versus log POW, the corresponding log POWof the peak was determined as - 0.25.Using the correlation log K / log POW, the log POW of the peak of test item PPDA was calcu-lated as -0.250 ± 0.002 (mean ± standard deviation). Due to the fact that the calculated logPOW-value of the test item lies below the calibrated range (0.30 -2.70), the log POW of PPDA should be stated as < 0.3.