Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
2-piperidin-2-ylethanol
EC Number:
216-059-2
EC Name:
2-piperidin-2-ylethanol
Cas Number:
1484-84-0
Molecular formula:
C7H15NO
IUPAC Name:
2-piperidin-2-ylethanol
Constituent 2
Reference substance name:
2-Piperidineethanol
IUPAC Name:
2-Piperidineethanol

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
0.263
Temp.:
22.5 °C
Remarks on result:
other: mean value

Applicant's summary and conclusion

Conclusions:
Partition coefficient log Pow for the TS was determined to be 0.263 (22.5 °C)