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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

The acute oral toxicity of Terracess P is low, with LD50> 2000 mg/kg body. The acute toxicity after inhalation is
also low (4h-LC50 > 5.04 g/m3). Therefore, an extensive toxicokinetic assessment is considered of limited
value. Below, an assessment of the anticipated toxicokinetic behaviour of Terracess P is given.  

The water solubility of Terracess P is very low (<36 microg/l), and should be considered a rate-limiting factor for
the absorption of the compound from the gastro-intestinal tract. Solubility might be increased by the low pH in the
stomach, which then may result in an increased absorption. However, also uptake of the smaller particles may take place by pinocytosis into intestinal cells. Mg2 + is the second most plentiful cation of the intracellular fluids. The average 70-kg adult has about 2000 mEq of Mg2+ in his body and the daily dietary intake is 0.25-0.50 g
daily. Approximately one third is absorbed from the gastro-intestinal tract. Chronic ingestion of Mg2 + causes only slight increases in plasma concentrations of Mg2+ in individuals with normal renal function.
Approximately 3 percent of an oral dose of titanium is absorbed. 

The estimated body burden of titanium is about 15 mg. Most of it is in the lungs, probably as a result of inhalation exposure. Inhaled titanium remains in the lungs for long periods. It has been estimated that about one third of the inhaled titanium is retained in the lungs. Lung burdens tend to increase with age.

The potassium, magnesium and titanium ions are primarily excreted renally. 

Dermal absorption of the compound is expected to be low. 

The anticipated kinetic behaviour is supported by the acute and semichronic toxicity data. The observed effects after inhalation of Terracess P are probably caused by precipitation of the substance in the lungs.

Based on this and the RIVM Risk assessment as performed in 2008 (BMS080702.11), values taken for absorption are: 50% for oral, 10% for dermal and 100% for inhalation absorption.