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Ecotoxicological information

Toxicity to birds

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Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according to a FIFRA guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
Deviations:
no
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Suttocide A (Powder}; Lot No. J15-150D with a purity of 97%.
Dose method:
other: a single dose of the test substance in diluent was orally intubated directly into the crop or proventriculus of each bird using a stainless steel cannula.
Analytical monitoring:
yes
Vehicle:
yes

Test organisms

Test organisms (species):
Colinus virginianus

Study design

Limit test:
no
Remarks:
1. Acclimation - 16 days. 2. Fasting - At least 15 hours prior to dosing. 3. Dosing - Experimental Start Date - October 12, 1990. 4. Post-dosing observation - 14 days.
No. of animals per sex per dose and/or stage:
5
Control animals:
yes

Results and discussion

Effect levels
Duration (if not bolus):
14 d
Dose descriptor:
LD50
Effect level:
> 2 250 mg/kg bw
Conc. / dose based on:
test mat.
Basis for effect:
mortality

Any other information on results incl. tables

There were no mortalities at the 486, 810 or 1350 mg/kg dosages. There was a single, incidental mortality at 292 mg/kg. There was 40% mortality (4 of 10) at 2250 mg/kg. Treatment related effectswere seen at 810 mg/kg and higher dosages. These effects were reversible even at the highest dosage. Signs of toxicity typical of intoxication with Suttocide A included ruffled appearance, lethargy, reduced reaction to external stimuli (sound and movement), lower limb weakness, depression, wing droop and coma.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The acute oral LD5O value for northern bobwhite exposed to Suttocide A as a single oral dosage was determined to be greater than 2250 mg/kg, the highest dosage tested. The no mortality level was 1350 mg/kg. The no observed effect level was 486 mg/kg based on signs of toxicity and a loss in body weight at 810 mg/kg.