Registration Dossier
Registration Dossier
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EC number: 214-507-1 | CAS number: 1137-42-4
Endpoint summary
Administrative data
Description of key information
Oral rat: LD50 12086 mg/kg
Behavioral: Somnolence (general depressed activity), Convulsions or effect on seizure threshold; Lungs, thorax or respiration: dyspnea (18-20 Vadkovskii per. Moscow, 101479, Russia; History Unknown (2), 25, 1994)
Oral mouse: LD50 3724 mg/kg
Behavioral: somnolence (general depressed activity), convulsions or effect on seizure threshold; Lungs, thorax or respiration: Dyspnea (18-20 Vadkovskii per. Moscow, 101479, Russia; History Unknown (2), 25, 1994)
Inhalation rat: TCLo 41.4 mg/m³/4H
Kidney, Ureter and bladder: other changes in urine composition; blood: changes in serum composition (e.g. TP, bilirubin, cholesterol; Biochemical: Enzyme inhibition, induction or change in blood tissue levels, Phosphatases)
(18-20 Vadkovskii per. Moscow, 101479, Russia; History Unknown (2), 25, 1994)
Read-across data captured from published Benzophenone registration dossier:
Oral mouse (OECD Guideline 401): LD50 ca. 2895 mg/kg bw (Caprino L et al., 1975, Eur J Toxicol Environ Hyg 9, 99-103)
Dermal rabbit (no guideline followed): LD50 3535 mg/kg bw (Opdyke DLJ, 1979, Food Cosmet Toxicol 11, 873-874)
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test and read-across data is reliable and suitable for classification purposes under Regulation (EC) No 1272/2008, as amended for the seventh time in Regulation (EC) No 2015/1221. As a result the substance is considered to be not classified for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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