Registration Dossier
Registration Dossier
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EC number: 276-675-2 | CAS number: 72479-28-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The test was performed following official guideline, some details on test conditions are missing. Study meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: similar to OECD 401
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 4-chloro-3-[4-[[5-chloro-2-(2-chlorophenoxy)phenyl]azo]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzenesulphonate
- EC Number:
- 276-675-2
- EC Name:
- Sodium 4-chloro-3-[4-[[5-chloro-2-(2-chlorophenoxy)phenyl]azo]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzenesulphonate
- Cas Number:
- 72479-28-8
- Molecular formula:
- C22H14Cl3N4NaO5S
- IUPAC Name:
- sodium 4-chloro-3-[4-[[5-chloro-2-(2-chlorophenoxy)phenyl]azo]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzenesulphonate
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Age: 5 weeks old- Weight: from 109 g male, 180 g female- Housing: 5 animals per cage - Diet: commercial pelleted diet (Oakes Special diet with added vit. E) ad libitum- Water: ad libitum ENVIRONMENTAL CONDITIONS- Temperature (°C): 21 ± 2- Photoperiod (hrs dark / hrs light): 12 h light / 12 h dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 15000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortality.
- Clinical signs:
- No clinical symptoms were recorder.
- Body weight:
- No data.
- Gross pathology:
- No damage to any organs.
- Other findings:
- No data.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: other: EU criteria
- Conclusions:
- The tested item was found to be non toxic for oral exposure with a LD50 > 8600 mg/kg bw.
- Executive summary:
The acute oral toxicity in rats of both sexes was assessed with this test over a period of 14 days.
The results show no toxicity with a LD50 value > 15000 mg/kg bw.
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