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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Radiolabelling:
no
Details on study design: HPLC method:
Determination of retention time
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System : Agilent Technologies 1100 Series, incorporating autosampler
Column : XSelect CN 5μ (150 x 4.6 mm id)
Column temperature : 30 ºC
Mobile phase : Methanol:water (55:45 v/v), ramped to 100% methanol for sample injections after the retention time of DDT
pH of mobile phase : 6.05
Flow-rate : 1.0 mL/min
Injection volume : 25 μL
UV detector wavelength : 210 nm

As the test item had a high affinity for the stationary phase of the column, the mobile phase was adjusted to 100% methanol shortly after the retention time of DDT to elute the sample.
Type:
Koc
Value:
> 427 000
Temp.:
30 °C
Type:
log Koc
Value:
> 5.63
Temp.:
30 °C
Details on results (HPLC method):
As the slope of the calibration curve for the reference standards showed good first order correlation and as the retention times between duplicate injections for each solution was consistent, the HPLC method was considered valid for the determination of adsorption coefficient. Based on the chromatographic data, the test item was considered to be stable during the test procedure.
Validity criteria fulfilled:
yes
Conclusions:
The adsorption coefficient of the test material was assessed according to OECD Guideline 121 and determined to be greater than 4.27 x 10E5, log10Koc >5.63.

Description of key information

Log10 Koc greater than 4.27 x 10E5, log10Koc >5.63.

Key value for chemical safety assessment

Koc at 20 °C:
427 000

Additional information

The adsorption coefficient of octadecanedioic acid dimethyl ester (ODDAME) was assessed according to OECD Guideline 121 and determined to be greater than 4.27 x 10E5, log10Koc >5.63.

[LogKoc: 5.63]