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EC number: 601-161-5 | CAS number: 112110-16-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-Pyridinedicarboxylic acid, 5-methyl-,dimethylester
- IUPAC Name:
- 2,3-Pyridinedicarboxylic acid, 5-methyl-,dimethylester
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): CL 301,589
- Physical state: solid, yellow powder
- Analytical purity: 99.5%
- Storage condition of test material: Room temp.
- Lot/batch No.: AC 9736-103
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Species / strain / cell type:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver S-9
- Test concentrations with justification for top dose:
- 0, 312.5, 625, 1250, 2500 and 5000 µg/Plate
- Vehicle / solvent:
- DMSO
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 2-nitrofluorene
- other: N-Methyl-N-nitro-N-nitrosoguanidine; 9-Aminoacridine hydrochloride, 2-Aminoanthracene
- Details on test system and experimental conditions:
- The test article was prepared fresh on the day(s) of testing at different concentrations in DMSO. The test material appeared to be fully soluble in the vehicle at all doses.
- Evaluation criteria:
- For each dose level, the mean value and standard deviation for revertants per plate were calculated. If the mean value for a given dose point was equal to or greater than twice the mean concurrent vehicle control value for TA98 and TA100 or three times the concurrent vehicle control for strains TA1535, TA1537, TA1538 and WP2 uvrA-, the result for that dose point was considered to be positive. A positive result for the assay is defined as a reproducible dose associated increase in the mean numbers of revertant colonies over at least three concentrations of the test material with at least one positive dose point.
The final decision regarding the genotoxic potential is guided by reasoned scientific judgment.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
2,3-Pyridinedicarboxylic acid, 5-methyl-, 2,3-dimethyl ester was judged to be negative for mutagenicity in six tester strains of bacteria up to and including a dose level of 5000 µg/plate in the presence and absence of S-9 metabolic activation, under the given test conditions. - Executive summary:
2,3-Pyridinedicarboxylic acid, 5-methyl-, 2,3-dimethyl ester was assayed in the microbial mutagenicity assay at concentrations up to and including 5000 µg/plate with and without metabolic activation (Aroclor induced rat liver S-9). The assay was conducted with six bacterial strains: S.typhimurium TA98, TA100, TA1535, TA1537, TA1538 and E.coli WP2 uvrA- using the plate incorporation assay method. Five dose levels were used with three replicates per dose point. The assay was conducted twice to confirm the results.
Results obtained in these assays indicated that the test material was not mutagenic at doses up to 5000 µg/plate with or without metabolic activation.
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