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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2012-03-07 to 2012-03-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
5
Remarks on result:
other: 1st measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
5
Remarks on result:
other: 2nd measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
7
Remarks on result:
other: 1st measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
7
Remarks on result:
other: 2nd measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
9
Remarks on result:
other: 1st measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
9
Remarks on result:
other: 2nd measurement
Details on results:
Because the test material was ionisable substance, the test was performed in the pH range relevant for the natural environment (pH range of 5.0-9.0) based on OECD Guideline 117.

The test substance was found to elute before 2-butanone and thefore logPow was set at <0.3 since regression equation could not be applied.

Regression equation of calibratiion curves at mobile phase were
pH 5.0: log Pow=1.399logk-0.3575, correlation coefficient 0.99
pH 7.0 : log Pow=1.409logk-0.3721, correlation coefficient 0.99
pH 9.0 : log Pow=1.406logk-0.3704, correlation coefficient 0.99
Conclusions:
logPow of the test substance at pH 5.0, 7.0 and 9.0 were all found to be <0.3.
Executive summary:

The partition coefficient of test item was determined using HPLC method  based on OECD guideline 117. Because the test material was ionisable substance, the test was performed in the pH range relevant for the natural environment (pH range of 5.0 to 9.0).

logPow of the test substance at pH 5.0, 7.0 and 9.0 were all found to be <0.3.

Description of key information

The partition coefficient of test item was determined using HPLC method  based on OECD guideline 117. Because the test material was ionisable substance, the test was performed in the pH range relevant for the natural environment (pH range of 5.0 to 9.0).

logPow of the test substance at pH 5.0, 7.0 and 9.0 were all found to be <0.3.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.3

Additional information