Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
7 March 2012 - 15 March 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP - Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): [trade name given]
- Physical state: White crystalline powder
- Storage condition of test material: At room temperature in the dark

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
5
Remarks on result:
other: 1st measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
5
Remarks on result:
other: 2nd measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
7
Remarks on result:
other: 1st measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
7
Remarks on result:
other: 2nd measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
9
Remarks on result:
other: 1st measurement
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
9
Remarks on result:
other: 2nd measurement
Details on results:
Because the test material was ionisable substance, the test was performed in the pH range relevant for the natural environment (pH range of 5.0-9.0)
based on OECD Guideline 117.


The test substance was found to elute before 2-butanone and thefore logPow was set at <0.3 since regression equation could not be applied.

Regression equation of calibratiion curves at mobile phase were
pH 5.0: log Pow=1.399logk-0.3575, correlation coefficient 0.99
pH 7.0 : log Pow=1.409logk-0.3721, correlation coefficient 0.99
pH 9.0 : log Pow=1.406logk-0.3704, correlation coefficient 0.99


Applicant's summary and conclusion