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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across from an analogue substance for which a guideline study (Klimish 1) is available.
Reason / purpose for cross-reference:
read-across source
Principles of method if other than guideline:
Read-across approach from experimental data (study according to OECD 203 and GLP) on an analogue substance P0310.
Key result
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
>= 124.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: Based on the read-across from an analogue substance.
Details on results:
Based on experimental results on analogue substance P0310 where 96h-NOEC was ≥ 100 mg/L (based on mortality), the read-across approach is applied and the 96h-NOEC for substance P-1057 is calculated to be ≥124.5 mg/L.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on read-across approach from analogue substance P0310, the NOEC (96h) of the substance P-1057 is calculated to be ≥ 124.5 mg/L.
Executive summary:

Based on experimental results obtained in a study according to OECD 203 on analogue substance P0310 where 96h-NOEC for zebra fish (Brachydanio rerio) was determined to be > 100 mg/L (based on mortality), the read-across approach is applied and the 96h-NOEC substance P-1057 is determined to be ≥124.5 mg/L.

Description of key information

Key study: Based on read-across approach from analogue substance P0310, the NOEC (96h) of the substance P-1057 was calculated to be ≥124.5 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
124.5 mg/L

Additional information

Key study: Based on experimental results (study according to OECD 203 and GLP) on analogue substance P0310 (96h-NOEC for zebra fish (Brachydanio rerio) >100 mg/L; based on mortality), the read-across approach was applied and the 96h-NOEC for substance P-1057 was determined to be ≥124.5 mg/L.