Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1949

Materials and methods

Principles of method if other than guideline:
Primary skin irritation was recorded in a 10-grade ordinal series and is based upon the severest reaction that developed on the clipped skin of each 5 albino rabbits within 24 hours of the uncovered application of undiluted sample or of solutions in water, propylene glycol, or acetone.
GLP compliance:
no

Test material

Constituent 1
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
open
Preparation of test site:
shaved
Vehicle:
other: undiluted sample or solutions in water, propylene glycol or acetone
Controls:
not specified
Amount / concentration applied:
0.01 mL (undiluted)
Duration of treatment / exposure:
24 hour(s)
Observation period:
no data
Number of animals:
5 animals
Details on study design:
SCORING SYSTEM:
- Method of calculation: Primary skin irritation was recorded in a 10-grade ordinal series and is based upon the severest reaction that developed on the clipped skin; Grade 1: indicated no irritation, Grade 2: least visible capillary injection from the undiluted chemical; Grade 3: strong capillary injection; grade 4: slight erythema; Grade 5: strong erythema, edema or slight necrosis; Grade 6: indicated necrosis when undiluted, Grade 10: indicated necrosis from a 0.01% solution;

Results and discussion

In vivo

Results
Remarks on result:
other:
Remarks:
The primary skin irritation was graded as 2.
Irritant / corrosive response data:
The primary skin irritation was graded as 2.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Based on the Harmonised classificatation Annesx VI of Regulation (EC) No 1272/2008 (CLP Regulation) the substance is classified as skin irritating cat. 2 (H315).