Registration Dossier
Registration Dossier
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EC number: 600-813-6 | CAS number: 1072-68-0
Endpoint summary
Administrative data
Description of key information
Additional information
Adsorption / Desorption:
In accordance with column 2 of REACH Annex VIII, the study does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient), or the substance and its relevant degradation products decompose rapidly.1,4-Dimethyl-1H-pyrazole(CAS 1072 -68 -0) has a log Kow of 0.95(@25°C, pH 6.1, Kurume, Report No. 80546, 1994), howeverthe substance is not readily biodegradable (see IUCLID-Chapter 5.2.1).
Estimates for 1,4 -Dimethyl-1H-pyrazole by the MCI method and the log-Kow method of KOCWIN v2.00 (EPISuite v4.11; BASF SE 2016) calculated
log Koc values of 1.72 (MCI) and 1.85 (log Kow). Due to the results an adsorption to solid phase is not expected. Furthermore, regarding the experimental estimated log Kow, high water solubility and poor biodegradation the product might trickles away and can be transported to deeper soil areas with larger water loads.
Henry’s Law Constant (HLC):
The Henry’s Law Constant was calculated by using the bond estimation method of HENRYWIN v3.20 (EPISuite v 4.11) to be 8.81 Pa*m³/mol. The estimation refers to the uncharged molecule. The substance is within the applicability domain of the model.
Based on the calculated data the substance is expected to slowly evaporate into the atmosphere from the water surface
Distribution Modelling:
Based on the results of the Mackay LEVEL I v3.00 calculation, over time, the substance will preferentially distribute into the compartment water (97.8%); the data refer to the uncharged molecule (pKa value: 2.77).
At environmentally relevant conditions, the substance is predominantly present in its uncharged form (pH 4: 91.5%; pH 7 & pH 9: 100% uncharged).
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