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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-02-26 to 2018-05-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD and EU guideline study, GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
no
Type of method:
effusion method: by loss of weight or by trapping vaporisate

Test material

Constituent 1
Chemical structure
Reference substance name:
4-amino-5-methyl-1,2-dihydropyridin-2-one
EC Number:
682-818-3
Cas Number:
95306-64-2
Molecular formula:
C6 H8 N2 O
IUPAC Name:
4-amino-5-methyl-1,2-dihydropyridin-2-one
Test material form:
solid

Results and discussion

Vapour pressureopen allclose all
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 hPa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 hPa
Key result
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0 hPa

Any other information on results incl. tables

The vapour pressure was measured in the temperature range of 50 °C to 110 °C. The measured vapour pressures at the corresponding temperatures are listed in Table 1. After the measurement a mass loss of approx. 0.03 % (w/w) was determined.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C//Vapour pressure / hPa

50//3.0 × 10-5*

60//1.4 × 10-5*

70//7.4 × 10-6*

80//9.2 × 10-6*

90//1.1 × 10-5

100//1.6 × 10-5

110//2.5 × 10-5

* Data point not included in the evaluation, due to a typical deviation caused by

volatile impurities at the beginning of a measurement.

The data points measured at 50 °C to 80 °C were not included in the evaluation because they showed a typical deviation caused by volatile impurities at the beginning of a measurement.

Figure 1 on page 7 gives the vapour pressure (logarithmic scale) as a function of the inverse temperature (1/T, T in Kelvin). Only for better readability the temperature is also reported in a centigrade scale. The values for 20, 25 and 50 °C are calculated, using the Antoine constants A, B and C as shown in Table 2.

Table 2: Antoine parameters and extrapolated vapour pressures

T / °C//p / hPa//log (p/hPa) =A + B/(C+T[°C])

20// 2.7 × 10-7//A =1.80534

25// 3.7 × 10-7//B =-2457.34

50// 1.6 × 10-6//C =273.15

Applicant's summary and conclusion

Conclusions:
The following vapour pressure values for the test item were extrapolated from the experimental data (vapour pressure balance):
20 °C: 2.7 × 10-7 hPa
25 °C: 3.7 × 10-7 hPa
50 °C: 1.6 × 10-6 hPa
Executive summary:

Title: 4-Amino-5-methylpyridinon, Batch No.: BXR7SWA, VAPOUR PRESSURE A.4. (OECD 104)

The purpose of this study was the determination of the vapour pressure of the test item according to:

European Commission Regulations (EC) No. 440/2008 and No. 761/2009,

-A.4. Vapour pressure: Effusion method

OECD test guideline,

-OECD 104 Vapour pressure

The following vapour pressure values for the test item were extrapolated from the experimental data (vapour pressure balance):

20 °C: 2.7 × 10-7 hPa

25 °C: 3.7 × 10-7 hPa

50 °C: 1.6 × 10-6 hPa

This study is classified acceptable and satisfies the guideline requirements for vapour pressure studies.

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