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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4-diethoxyphenethylamine
EC Number:
262-752-8
EC Name:
3,4-diethoxyphenethylamine
Cas Number:
61381-04-2
Molecular formula:
C12H19NO2
IUPAC Name:
3,4-diethoxyphenethylamine
Test material form:
liquid

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes
Remarks:
water

Test organisms

Test organisms (species):
Daphnia magna
Details on test organisms:
The Daphnia introduced in the test were taken from ibacon's in-house laboratory culture.

Study design

Test type:
static
Total exposure duration:
48 h

Test conditions

Hardness:
2.5 mmol/L (= 250 mg/L) as CaCO3
Test temperature:
20 °C at test start;
19 °C at test end
pH:
8.0 to 8.1 at test start;
7.9 at test end
Dissolved oxygen:
8.6 to 9.0 mg/L at test start;
7.9 to 8.3 mg/L at test end
Nominal and measured concentrations:
100, 50, 25, 12.5, and 6.25 mg test item/L and a control

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
ca. 50 mg/L
Nominal / measured:
nominal
Basis for effect:
mobility
Details on results:
The toxic effect of the test item Diethoxy Amine (CAS 61381-04-2) to Daphnia magna was assessed in a static dose-response test. The 48-hour NOEC was determined to be 50 mg test item/L. The 48-hour
LOEC was determined to be 100 mg test item/L and the 48-hour EC50 value was determined to be > 100 mg test item/L.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The toxic effect of the test item Diethoxy Amine (CAS 61381-04-2) to Daphnia magna was assessed in a static dose-response test. The 48-hour NOEC was determined to be 50 mg test item/L. The 48-hour EC50
value was determined to be > 100 mg test item/L.