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EC number: 282-316-0 | CAS number: 84145-95-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental Starting Date: 17 November 2015; Experimental Completion 27 November 2015; Study Completion Date: 22 December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Identification: FAT 20013/D TE Lot: 1502011
Appearance: Black powder - Analytical method:
- photometric method
- Key result
- Type:
- Pow
- Partition coefficient:
- 37.97
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not available
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.57
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not available
- Conclusions:
- The n-octanol/water partition coefficent (log Pow) of the test item at 20 °C was determined to be 1.57.
- Executive summary:
The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. Flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition co-efficient (log Pow) of FAT 20013 at 20°C was determined to be 1.57 (Pow = 37.97).
Reference
Preliminary Visual Estimation of the n-octanol solubility
An amount of the test item were stirred with different amounts of n-octanol at room temperature and visually checked for any undissolved particles.
Amount of test item in mg |
Volume in ml |
Total volume in ml |
Stirring time |
Appearance of mixture |
10 |
1 |
1 |
60 min |
undissolved |
|
2 |
3 |
60 min |
undissolved |
|
2 |
5 |
60 min |
dissolved |
According to this preliminary test the solubility of the test item in n-octanol is about 2 g/l (without correction of the purit
Determination of the solubility in the n-Octanol phase: FlaskMethod
Experiment |
A |
B |
C |
D (blank) |
Amount of test item (mg) |
1000 |
1000 |
1000 |
-- |
Stirring time at 30 °C (h) |
24 |
48 |
72 |
72 |
Measured concentration (mg/l) |
8,3 |
5,9 |
6,5 |
-- |
Dilution |
0,025ml/10ml |
0,025ml/10ml |
0,025ml/10ml |
-- |
n-Octanol solubility (g/l) |
3,33 |
2,36 |
2,59 |
-- |
Average experiments A to C: 2.8g/l
Description of key information
The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. Flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition co-efficient (log Pow) of FAT 20013 at 20°C was determined to be 1.57 (Pow = 37.97).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.57
- at the temperature of:
- 20 °C
Additional information
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