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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental Starting Date: 17 November 2015; Experimental Completion 27 November 2015; Study Completion Date: 22 December 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Identification: FAT 20013/D TE Lot: 1502011
Appearance: Black powder
Analytical method:
photometric method
Key result
Type:
Pow
Partition coefficient:
37.97
Temp.:
20 °C
Remarks on result:
other: pH is not available
Key result
Type:
log Pow
Partition coefficient:
1.57
Temp.:
20 °C
Remarks on result:
other: pH is not available

Preliminary Visual Estimation of the n-octanol solubility

An amount of the test item were stirred with different amounts of n-octanol at room temperature and visually checked for any undissolved particles.

Amount of test item in mg

Volume in ml

Total volume in ml

Stirring time

Appearance of mixture

10

1

1

60 min

undissolved

 

2

3

60 min

undissolved

 

2

5

60 min

dissolved

According to this preliminary test the solubility of the test item in n-octanol is about 2 g/l (without correction of the purit

Determination of the solubility in the n-Octanol phase: FlaskMethod

Experiment

A

B

C

D (blank)

Amount of test item (mg)

1000

1000

1000

--

Stirring time at 30 °C (h)

24

48

72

72

Measured concentration (mg/l)

8,3

5,9

6,5

--

Dilution

0,025ml/10ml

0,025ml/10ml

0,025ml/10ml

--

n-Octanol solubility (g/l)

3,33

2,36

2,59

--

Average experiments A to C: 2.8g/l

Conclusions:
The n-octanol/water partition coefficent (log Pow) of the test item at 20 °C was determined to be 1.57.
Executive summary:

The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. Flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition co-efficient (log Pow) of FAT 20013 at 20°C was determined to be 1.57 (Pow = 37.97).

Description of key information

The n-octanol/water partition coefficient of the test item was evaluated in a study conducted according to the EU Method A.8, OECD Guideline 107 and OECD Guideline 117. Flask method was used for this purpose. Based on the findings of the study, the n-octanol/water partition co-efficient (log Pow) of FAT 20013 at 20°C was determined to be 1.57 (Pow = 37.97).

Key value for chemical safety assessment

Log Kow (Log Pow):
1.57
at the temperature of:
20 °C

Additional information

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