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Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data are given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970

Materials and methods

Type of study / information:
Skin irritation with eight male subjects.
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
Skin irritation with eight male subjects.
GLP compliance:
no
Remarks:
pre-GLP study

Test material

Constituent 1
Chemical structure
Reference substance name:
4H-3,1-benzoxazine-2,4(1H)-dione
EC Number:
204-255-0
EC Name:
4H-3,1-benzoxazine-2,4(1H)-dione
Cas Number:
118-48-9
Molecular formula:
C8H5NO3
IUPAC Name:
4H-3,1-benzoxazine-2,4(1H)-dione
Details on test material:
Isatoic acid, technical grade; no further data

Method

Ethical approval:
not specified

Results and discussion

Results:
Application of the unchanged test substance to the forearm skin of volunteers for 24 hours under semiocclusive conditions did not produce any sign of irritation.



Applicant's summary and conclusion