Registration Dossier
Registration Dossier
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EC number: 204-846-3 | CAS number: 127-51-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance material review on the given test chemical
- Author:
- Lalko et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment on test chemical
- Author:
- Belsito et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- publication
- Title:
- Assessment Report - Test chemical
- Author:
- ADAMS et al.
- Year:
- 1 996
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- publication
- Title:
- SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES
- Author:
- World Health Organization
- Year:
- 1 999
- Bibliographic source:
- World Health Organization
- Reference Type:
- secondary source
- Title:
- Toxicity Studies - Test chemical
- Author:
- RTECS
- Year:
- 2 011
- Bibliographic source:
- Registry of Toxic Effects of Chemical Substances
- Reference Type:
- secondary source
- Title:
- Acute Toxicity Studies on Test Chemical
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 017
- Bibliographic source:
- High Production Volume (HPV)
- Reference Type:
- secondary source
- Title:
- Hazard Characterization - Test chemical
- Author:
- U. S. Environmental Protection Agency (EPA)
- Year:
- 2 010
- Bibliographic source:
- U. S. Environmental Protection Agency (EPA)
- Reference Type:
- secondary source
- Title:
- Toxicity Summaries - Test chemical
- Author:
- US EPA
- Year:
- 2 002
- Bibliographic source:
- US EPA
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- EC Number:
- 204-846-3
- EC Name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- Cas Number:
- 127-51-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
- Details on test material:
- - IUPAC Name: (3E)-3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- Common Name: Alpha-isomethylionone
- InChI: 1S/C14H22O/c1-10-7-6-8-14(4,5)13(10)9-11(2)12(3)15/h7,9,13H,6,8H2,1-5H3/b11-9+
- Smiles: C1([C@@H](\C=C(\C(C)=O)C)C(=CCC1)C)(C)C
- Molecular formula : C14H22O
- Molecular weight : 206.327 g/mole
- Substance type:Organic
- Physical state:Liquid, slightly yellow color
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- Total = 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: Observations for mortality and systemic effects were made over a 14-day period. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at 5000 mg/kg bw
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral toxicity dose (LD50) value was considered to be >5000 mg/kg bw, when 10 rats were treated with the given test chemical via oral gavage route.
- Executive summary:
Acute oral toxicity study was conducted by using test chemical in 10 rats at the dose concentration of 5000 mg/kg bw. Observations for mortality and systemic effects were made over a 14-day period.No mortality was observed at 5000 mg/kg bw.
Hence, the LD50 value was considered to be >5000 mg/kg bw, when 10 rats were treated with the given test chemical via oral gavage route.
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