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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance material review on the given test chemical
Author:
Lalko et al.
Year:
2007
Bibliographic source:
Food and Chemical Toxicology
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment on test chemical
Author:
Belsito et al.
Year:
2007
Bibliographic source:
Food and Chemical Toxicology
Reference Type:
publication
Title:
Assessment Report - Test chemical
Author:
ADAMS et al.
Year:
1996
Bibliographic source:
Food and Chemical Toxicology
Reference Type:
publication
Title:
SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES
Author:
World Health Organization
Year:
1999
Bibliographic source:
World Health Organization
Reference Type:
secondary source
Title:
Toxicity Studies - Test chemical
Author:
RTECS
Year:
2011
Bibliographic source:
Registry of Toxic Effects of Chemical Substances
Reference Type:
secondary source
Title:
Acute Toxicity Studies on Test Chemical
Author:
U.S. Environmental Protection Agency
Year:
2017
Bibliographic source:
High Production Volume (HPV)
Reference Type:
secondary source
Title:
Hazard Characterization - Test chemical
Author:
U. S. Environmental Protection Agency (EPA)
Year:
2010
Bibliographic source:
U. S. Environmental Protection Agency (EPA)
Reference Type:
secondary source
Title:
Toxicity Summaries - Test chemical
Author:
US EPA
Year:
2002
Bibliographic source:
US EPA

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of the given test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
EC Number:
204-846-3
EC Name:
3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
Cas Number:
127-51-5
Molecular formula:
C14H22O
IUPAC Name:
3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
Details on test material:
- IUPAC Name: (3E)-3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- Common Name: Alpha-isomethylionone
- InChI: 1S/C14H22O/c1-10-7-6-8-14(4,5)13(10)9-11(2)12(3)15/h7,9,13H,6,8H2,1-5H3/b11-9+
- Smiles: C1([C@@H](\C=C(\C(C)=O)C)C(=CCC1)C)(C)C
- Molecular formula : C14H22O
- Molecular weight : 206.327 g/mole
- Substance type:Organic
- Physical state:Liquid, slightly yellow color

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
5000 mg/kg
No. of animals per sex per dose:
Total = 10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: Observations for mortality and systemic effects were made over a 14-day period.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed at 5000 mg/kg bw
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute oral toxicity dose (LD50) value was considered to be >5000 mg/kg bw, when 10 rats were treated with the given test chemical via oral gavage route.
Executive summary:

Acute oral toxicity study was conducted by using test chemical in 10 rats at the dose concentration of 5000 mg/kg bw. Observations for mortality and systemic effects were made over a 14-day period.No mortality was observed at 5000 mg/kg bw.

Hence, the LD50 value was considered to be >5000 mg/kg bw, when 10 rats were treated with the given test chemical via oral gavage route.