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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 March 1999
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
not specified
GLP compliance:
not specified
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Code number of the test material: FAT 93460/A
- Source and batch No.of test material: EN 037098A7
- Expiration date of the batch: November 2003

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature

OTHER SPECIFICS:
- Purity: ca 23 %
- Appearance: yellow, solid
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
not specified
Water media type:
not specified
Limit test:
no
Total exposure duration:
48 h
Test temperature:
21 °C.
pH:
7.9 - 8.0 (reported for 100 mg/L concentration only)
Dissolved oxygen:
97 % (reported for 100 mg/L concentration only)
Nominal and measured concentrations:
0, 10 and 100 mg/L (nominal concentrations)
Details on test conditions:
EFFECT PARAMETERS MEASURED: % Immobility (24 h and 48 h)
VEHICLE CONTROL PERFORMED: yes
Reference substance (positive control):
no
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Details on results:
Only one animal was found to be immobilised at the concentration of 100 mg/L, while no immobilisation was reported at 0 and 10 mg/L concentrations.
Validity criteria fulfilled:
yes
Conclusions:
The EC50 of the test substance was determined to be >100 mg/L.
Executive summary:

The acute toxicity of the test substance to daphnia was investigated in a study conducted according to OECD Guideline 202. Three groups each containing 10 daphnids, were exposed to the test concentrations of 0, 10 and 100 mg/L for 48 hours and observed for immobilisation. The observations were recorded at 24 and 48 hours during the exposure. Only one animal was found to be immobilised at the concentration of 100 mg/L, while no immobilisation was reported at 0 and 10 mg/L concentrations. Hence, based on the observations the EC50 of the test substance was determined to be >100 mg/L.

Description of key information

The acute toxicity of the test substance to daphnia was investigated in a study conducted according to OECD Guideline 202. Three groups each containing 10 daphnids were exposed to the test concentrations of 0, 10 and 100 mg/L for 48 hours and observed for immobilisation. The observations were recorded at 24 and 48 hours during the exposure. Only one daphnid was found to be immobilised at the concentration of 100 mg/L, while no immobilisation was reported at 0 and 100 mg/L concentrations. Hence, based on the observations the EC50 of the test substance was determined to be >100 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
100 mg/L

Additional information