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EC number: 204-494-0 | CAS number: 121-71-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity to Deer Mice
- Author:
- Schafer et al..
- Year:
- 1 985
- Bibliographic source:
- Archives of Environmental Contamination and Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute oral toxicity for 3-Acetylphenol in deer mice was observed.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3'-hydroxyacetophenone
- EC Number:
- 204-494-0
- EC Name:
- 3'-hydroxyacetophenone
- Cas Number:
- 121-71-1
- Molecular formula:
- C8H8O2
- IUPAC Name:
- 1-(3-hydroxyphenyl)ethan-1-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 3'-hydroxyacetophenone
- Molecular formula (if other than submission substance): C8-H8-O2
- Molecular weight (if other than submission substance): 136.149
- Smiles notation (if other than submission substance): c1(cc(ccc1)O)C(C)=O
- InChl (if other than submission substance): 1S/C8H8O2/c1-6(9)7-3-2-4-8(10)5-7/h2-5,10H,1H3
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- other: (mice)Peromyscus maniculatus
- Strain:
- other: deer
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wild-trapped deer mice
- Age at study initiation: No data available
- Weight at study initiation: 20 gm
- Fasting period before study: No data available
- Housing: 2-4 individually caged deer mice.
- Diet (e.g. ad libitum): An alternate less preferred food (laboratory rodent pellets available ad lib.
- Water (e.g. ad libitum): water was available ad lib.
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water, corn oil, or 1.0% carbopol
- Details on oral exposure:
- DOSAGE PREPARATION (if unusual): geometrically spaced dosage level were used.
- Doses:
- No data available
- No. of animals per sex per dose:
- 2-4 animals.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration- 3 days
- Statistics:
- Thompson (1948) and Thompson and Weil (1952).
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 1 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Approximate mortality
- Mortality:
- Approximate 50 % mortality may observed in treated mice by range-finding modification.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- Therefore, LD0 was considered to be 1600 mg/kg bw when deer (Peromyscus maniculatus) mice treated with 3-Acetylphenol orally by gavage.
- Executive summary:
Ina a acute oral toxicity was evaluated in deer Peromyscus maniculatus) mice by using 3-Acetylphenol orally by gavage using water, corn oil, or 1.0% carbopol as carriers, followed by 3-days of observations for mortality. Approximate Lethal Dose was observed between 470-1600 mg/kg bw. ALD (Approximate Lethal Dose) represented a range-finding modification of the Deichman and LeBlanc (1943) and not the LD50 determination. Using this single animal per level method, each succeeding treatment was 50% higher than the preceding level and continued until mortality occurred and No 50 % mortality was observed in treated mice at 1600 mg/kg bw. Therefore, LD0 was considered to be 1600 mg/kg bw when deer (Peromyscus maniculatus) mice treated with 3-Acetylphenol orally by gavage.
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