Trisodium 1-amino-4-[[3-[[4-chloro-6-[(3-sulphonatophenyl)amino]-1,3,5-triazin-2-yl]amino]-2,4,6-trimethyl-5-sulphonatophenyl]amino]-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative density

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that the source and the target substance have very similar physicochemical and (eco)toxicological properties because their chemical structures are nearly identical. An analogue approach has thus been employed. The target substance is the meta-isomer of the dye Reactive Blue 049, where the sulphonate group is bound at the meta-position of the aminobenzene moiety. The source chemical is the reaction mass of both the meta-isomer and the para-isomer of Reactive Blue 049.
The presence of sulphonate groups make both dyes highly water soluble and therefore less critical for human health and environmental issues. Based on their chemical similarity, similar properties are expected in both humans and the environment.

2. SOURCE AND TARGET CHEMICAL(S)
Source: Reactive Blue 49 meta/para (CAS# 72214-18-7 / EC# 276-481-8)
Target: Reactive Blue 49 meta (CAS# 72927-99-2 / EC# 277-040-2)

3. ANALOGUE APPROACH JUSTIFICATION
see attachment under 4.2 Melting point / freezing point

Reason / purpose for cross-reference:

read-across source

Type:

density

Density:

1.416 g/cm³

Temp.:

20 °C

Key result

Type:

relative density

Density:

1.416 other: dimensionless

Temp.:

20 °C

Conclusions:

Average relative density of test substance at 20 °C temperature was found to be 1.4163

Executive summary:

Average relative density of the test substance was determined according to OECD Guideline 109. Average relative density of test substance at 20 °C temperature was found to be 1.4163

Reference 2

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2014

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Principles of method if other than guideline:

None

GLP compliance:

no

Type of method:

pycnometer method

Type:

density

Density:

1.416 g/cm³

Temp.:

20 °C

Key result

Type:

relative density

Density:

1.416 other: dimensionless

Temp.:

20 °C

Density of the test substance according to OECD guideline 109:

Measurement	1	2	3	4
ρ 20°C(sample) [g/cm³]	1.4279	1.4135	1.3879	1.4360

average ρ 20°C(test substance): 1.4163 g/cm³

Conclusions:

Average relative density of test substance at 20 °C temperature was found to be 1.4163

Executive summary:

Average relative density of the test substance was determined according to OECD Guideline 109. Average relative density of test substance at 20 °C temperature was found to be 1.4163

Description of key information

Average relative density at 20 °C was found to be 1.4163

Key value for chemical safety assessment

Relative density at 20C:

1.416

Additional information

Average relative density of the source substance was determined according to OECD Guideline 109. Average relative density at 20°C was found to be 1.4163. The structurally related target chemical will have a similar density.