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Administrative data

Endpoint:
oxidising solids
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is not GLP and does not follow the OECD Guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.17 (Oxidising Properties (Solids))
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
EC Number:
255-464-9
EC Name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Cas Number:
41621-49-2
Molecular formula:
C12H17NO2.C2H7NO
IUPAC Name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Test material form:
solid: particulate/powder

Results and discussion

Test results (Oxidising solids)open allclose all
Sample tested:
other: 70:30 sample-to-cellulose ratio
Parameter:
burning rate
Result:
90 s
Sample tested:
1:1 sample-to-cellulose ratio
Parameter:
burning rate
Result:
60 s
Sample tested:
other: 30:70 sample-to-cellulose ratio
Parameter:
burning rate
Result:
60 s
Sample tested:
other: 10:90 sample-to-cellulose ratio
Parameter:
burning rate
Result:
330 s

Any other information on results incl. tables

The sample was used as it is without any grinding or any other manipulation.

Cellulose was dried in an oven at 105° at ambient pressure for 16 hrs.

The ignition source was a flame from a gas burner.

A preliminary test was performed. Since the cone generated a vigorous reaction, the train test was carried out.

Several mistures of the prduct and cellulose were prepared (see table). The product burns with a vigorous flame emitting a black smoke.

 Product % w/w  Cellulose % w/w  Burning rate 20 cm in  Complete combustion (external)
 70  30  90''  180''
 50  50  60''  180''
 30  70  60''  150''
 10  90  330''  390''

A blank was performed by mixing 50% of Ba(NO3)2 and 50% of cellulose: the burning rate of this mixture is much slower than that of Cyclopirox olamine hence cyclopirox olamine must be considered an oxidizing substance.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (strong oxidising solids) based on GHS criteria
Conclusions:
Ciclopirox olamine is considered as oxidizing.

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