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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Principles of method if other than guideline:
A calibration curve was prepared based on absorbance measurements of ciclopirox olamine solutions at three known concentrations. The calibration function was used to estimate ciclopirox olamine concentration of its saturated solution.
GLP compliance:
no
Type of method:
other: Absorbance measurement of ciclopirox olamine saturated solution.

Test material

Constituent 1
Chemical structure
Reference substance name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
EC Number:
255-464-9
EC Name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Cas Number:
41621-49-2
Molecular formula:
C12H17NO2.C2H7NO
IUPAC Name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Test material form:
solid: particulate/powder

Results and discussion

Water solubility
Water solubility:
31 300 mg/L
Conc. based on:
test mat. (dissolved fraction)
Temp.:
25 °C
pH:
ca. 9

Applicant's summary and conclusion

Conclusions:
Water solubility of Ciclopirox olamine is 31300 mg/l at 25°C.