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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Study of Medical Supplies
Author:
Iyakuhin Kenkyu
Year:
1977
Bibliographic source:
Study of Medical Supplies. Vol. 8, Pg. 107, 1977.

Materials and methods

Principles of method if other than guideline:
Data published. No detailed information about principles of method are available.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
EC Number:
255-464-9
EC Name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Cas Number:
41621-49-2
Molecular formula:
C12H17NO2.C2H7NO
IUPAC Name:
6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Test material form:
solid: particulate/powder

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 350 mg/kg bw
Based on:
not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 oral (rat) for Ciclopirox Olamine is 2350 mg/kg bw