6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro cytogenicity / chromosome aberration study in mammalian cells

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

SIDS INITIAL ASSESSMENT PROFILE for 2-aminoethanol

Author:

OECD

Year:

2013

Bibliographic source:

OECD SIDS INITIAL ASSESSMENT PROFILE

Materials and methods

Principles of method if other than guideline:

Data published. No detailed information about principles of method are available.

GLP compliance:

not specified

Remarks:

Data published. No detailed information about GLP compliance.

Type of assay:

other: In vitro mammalian chromosome aberration test

Test material

Test material information

Constituent 1

Reference substance name:

2-aminoethanol

EC Number:

205-483-3

EC Name:

2-aminoethanol

Cas Number:

141-43-5

Molecular formula:

C2H7NO

IUPAC Name:

2-aminoethanol

Test material form:

liquid

Results and discussion

Test results

Species / strain:

hepatocytes: rat hepatocytes

Metabolic activation:

not specified

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

not specified

Applicant's summary and conclusion

Conclusions:

2-aminoethanol (the neutral form of Ethanolaminium cation) was negative in vitro cytogenicity / chromosome aberration study in mammalian cells.