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EC number: 701-015-1 | CAS number: 2156592-72-0
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- Endpoint summary
- Appearance / physical state / colour
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Laboratory study in experienced laboratory.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.
- EC Number:
- 287-494-3
- EC Name:
- Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs.
- Cas Number:
- 85536-14-7
- Molecular formula:
- SO3C7H8-(CH2)n with n= 9-12
- IUPAC Name:
- Benzenesulfonic acid, 4-C10-13-sec-alkyl derivs
- Reference substance name:
- Benzenesulphonic acid, 4-C10-13-sec-alkyl derivatives (LABS)
- IUPAC Name:
- Benzenesulphonic acid, 4-C10-13-sec-alkyl derivatives (LABS)
- Details on test material:
- Benzenesulfonic acid, C10-13-alkyl derivatives (85536-14-7)
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Male and female white New Zealand rabbits weight between 3.7 and 6.0 kg each. Animals were marked with a 5 digit number and held in steel cages. They were acclimated for 14 days prior to testing. Standard rabbit diet and water was provided ad libitum. Room temperature was held at 20 degrees C +/- 1 degree C, humidity at 60 +/- 5%, with a 12/12 hour light/dark cycle.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Single treatment that was not washed out.
- Observation period (in vivo):
- 1, 24, 48, and 72 hours and at 6 days after application.
- Number of animals or in vitro replicates:
- 6 (3 male, 3 female)
- Details on study design:
- Treatment was to the right eye with lower lid removed. The left eye was untreated and served as the control. The eyes were not washed out during the test. Observations were made at 1, 24, 48, and 72 hours and at 6 days after application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, and 72 hrs and 6 days
- Score:
- 46.9
- Reversibility:
- not fully reversible within: 6 days
- Remarks on result:
- other: moderately irritating
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Data not available
- Irritant / corrosive response data:
- Results indicated a moderate irritancy, but because of the intensity of the necrosis formation, the study was stopped at day 6.
Any other information on results incl. tables
Results of Eye Irritation Study in Rabbits
Observation |
Endpoint |
Male 11655 |
Male 11715 |
Male 11771 |
Female 11798 |
Female 11804 |
Female 11838 |
1 hr |
Cornea degree |
1 |
1 |
2 |
2 |
2 |
1 |
1 hr |
Cornea range |
4 |
4 |
4 |
4 |
4 |
4 |
1 hr |
Iris |
1X |
1X |
1X |
1X |
1X |
1X |
1 hr |
Conjunctiva redness |
3N |
3N |
3N |
2N |
3N |
3N |
1 hr |
Conjunctiva edema |
1 |
1 |
1 |
1 |
2 |
2 |
1 hr |
Conjunctiva - exsudation |
3 |
3 |
3 |
3 |
3 |
3 |
24 hrs |
Cornea -degree |
1 |
1 |
2 |
2 |
3C |
1 |
24 hrs |
Cornea range |
4 |
4 |
4 |
4 |
2 |
4 |
24 hrs |
Iris |
1* |
1* |
1* |
1* |
1*- |
1* |
24 hrs |
Conjunctiva redness |
3N |
3N |
3N |
3N |
3N S |
3N |
24 hrs |
Conjunctiva edema |
2 |
2 |
2 |
2 |
2 |
3 |
24 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
48 hrs |
Cornea degree |
1 |
1 |
2 |
2 |
3C |
1 |
48 hrs |
Cornea - range |
4 |
4 |
4 |
4 |
2 |
4 |
48 hrs |
Iris |
1* |
1* |
1* |
1* |
1*- |
1* |
48 hrs |
Conjunctiva redness |
3N S |
3N |
3N S |
3N S |
3N S |
3N S |
48 hrs |
Conjunctiva edema |
2 |
1 |
1 |
1 |
2 |
3 |
48 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
72 hrs |
Cornea degree |
1 |
1 |
1 |
2 |
4C |
1 |
72 hrs |
Cornea - range |
4 |
2 |
4 |
4 |
2 |
4 |
72 hrs |
Iris |
1X |
1X |
1* |
1* |
1*- |
1* |
72 hrs |
Conjunctiva - redness |
3N S |
3N S |
3N S |
3N S |
3N S |
3N S |
72 hrs |
Conjunctiva edema |
2 |
2 |
2 |
2 |
2 |
2 |
72 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Cornea degree |
2 |
2 |
2 |
2 |
4C |
2 |
6 days |
Cornea -range |
3 |
3 |
2 |
3 |
2 |
4 |
6 days |
Iris |
1X |
1X |
1* |
1* |
1*- |
1* |
6 days |
Conjunctiva - redness |
3N S L |
3N L |
3N L H |
3N S L |
3N S L |
3N S L |
6 days |
Conjunctiva edema |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Conjunctiva - exsudation |
2 |
1 |
2 |
2 |
2 |
2 |
C Cornea cloudy
X Parts of the iris turned red
* - Iris turned red
- - Retarded iris reaction
N Necrosis and corrosion of the conjunctiva
S Secretion formation
L Lids became encrusted
H Holding head inclined
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Result: moderately irritating
- Executive summary:
The eyes of six rabbits were treated with the test substance and observed for six days. Results indicate that the substance was moderately irritating but because of the intensity of the necrosis formation the study was stopped at day 6.
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