Registration Dossier
Registration Dossier
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EC number: 217-992-8 | CAS number: 2033-24-1
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- other: read across based on OECD Toolbox v3.4
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- See attached full OECD Toolbox study results
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 016
- Bibliographic source:
- OECD Toolbox v3.4.0.17
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2-dimethyl-1,3-dioxane-4,6-dione
- EC Number:
- 217-992-8
- EC Name:
- 2,2-dimethyl-1,3-dioxane-4,6-dione
- Cas Number:
- 2033-24-1
- Molecular formula:
- C6H8O4
- IUPAC Name:
- 2,2-dimethyl-1,3-dioxane-4,6-dione
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 45/54d
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- NOEL
- Effect level:
- 264 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: According to OECD TG422
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
