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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from RTECS database

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicty of CAS no 111-26-2
Author:
RTECS
Year:
2001
Bibliographic source:
EPA TSCA Section 8(b) CHEMICAL INVENTORY DATA BASE, JANUARY 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: asbelow
Principles of method if other than guideline:
Acute oral toxicity study of hexylamine in rabbit
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexylamine
EC Number:
203-851-8
EC Name:
Hexylamine
Cas Number:
111-26-2
Molecular formula:
C6H15N
IUPAC Name:
hexan-1-amine
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): n- hexylamine
- Molecular formula (if other than submission substance): C6H15N
- Molecular weight (if other than submission substance): 101.191 g/mole
- Substance type: organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
318.48 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
No data available
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 318.48 mg/k bw when rabbits were treated with Hexylamine by dermal application.
Executive summary:

In a acute dermal toxicity study, rabbits were treated with Hexylamine by dermal application. 50 % mortality observed in treated rabbits at 318.48 mg/k bw . Therefore, LD50 was considered to be 318.48 mg/k bw when rabbits were treated with Hexylamine by dermal application.