Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 206-525-3 | CAS number: 352-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
TFMEA is reported to be a clear colourless liquid at 20°C and 1013 hPa (visual assessment during test on physicochemical properties (melting point)).
The melting point of TFMEA was determined according to OECD Guideline 102, adopted 27th July 1995, and EU Method A.1, May 2008 by differential scanning calorimetry. The melting point of TFMEA is reported to be -46.6°C at 1013 hPa.
The boiling point of TFMEA is reported to be 108°C at 1013 hPa (determined according to OECD Guideline 103, adopted 27th July 1995, and EU Method A.2, May 2008, Siwoloboff method).
The density of TFMEA is reported to be 1 .1769 g/cm³ at 20°C (determined according to OECD Guideline 109, adopted 27th July 1995 and EU Method A.3, May 2008; pycnometer method).
In accordance with column 2 of REACH regulation annex VII, a granulometry test does not need to be conducted as the substance is a liquid.
The vapour pressure of TFMEA was determined according to OECD guideline 104, adopted 23 March 2006 and EU method A.4, May 2008. The vapour pressure was2200 Pa at 20°C, 3000 Pa at 25°C and 11000 Pa at 50°C.
The n-Octanol/Waterpartition coefficient (log Kow) of TFMEA was determined according to OECD Guideline 117, adopted 13 April 2004, and EU Method A.8, 30 May 2008; HPLC method. The log Kow was 2.3 at 23.3°C.
The water solubility of TFMEA was determined according to OECD Guideline 105, adopted 27th July 1995 and EU Method A.6, 30 May 2008; flask method. The water solubility of TFMEAis 906 mg/L (pH 6.2) at 20°C.
In accordance with column 2 of REACH regulation annex VII, surface tension testing does not need to be conducted. Based on structure, no surface activity is expected. The test substance is not used as detergent.
The flash point of TFMEA was determined according to EU test method A.9, 30 May 2008 (equilibrium method closed cup). The flash point of TFMEA is reported to be 19.5°C at 1013 hPa.
The auto-ignition temperature of TFMEA was determined according to EU test method A.15, 30 May 2008, and DIN 51794).The auto-ignition temperature is reported to be 425°C at 998.8 hPa.
According to REACH Regulation (Annex XI, 1.), the study on flammability does not need to be conducted if the available data are sufficient for assessment. For TFMEA, tests on flash point and auto-ignition are available. Pyrophoricity and flammability on contact with water are not expected based on a consideration of the structure of the substance.
In accordance with column 2 of REACH regulation annex VII, explosive properties testing does not need to be conducted as there are no chemical groups associated with explosive properties in the molecule.
In accordance with column 2 of REACH regulation annex VII, oxidising properties testing does not need to be conducted on the basis of chemical structure.
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