Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-525-3 | CAS number: 352-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1994-12-08 to 1994-12-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- 31 July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted 24 February 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2,2-trifluoroethyl methacrylate
- EC Number:
- 206-525-3
- EC Name:
- 2,2,2-trifluoroethyl methacrylate
- Cas Number:
- 352-87-4
- Molecular formula:
- C6H7F3O2
- IUPAC Name:
- 2,2,2-trifluoroethyl methacrylate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): TRIFLUOROETHYL METHACRYLATE (MATRIFE)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley ICO: OFA-SD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: app. 8 weeks
- Weight at study initiation: 266±9 g (males), 218±6 g (females)
- Fasting period before study: no
- Housing: individually during treatment
- Diet (e.g. ad libitum): pelleted diet, ad libitum
- Water (e.g. ad libitum): 0.22 µm filtered water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21±2°C
- Humidity (%): 30-70%
- Air changes (per hr): app. 12/h
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 5x6 cm (females), 5x7 cm (males)
- % coverage: app. 10% of the body surface
- Type of wrap if used: test substance and gauze pad were held in contact with the skin by means of an adhesive hypoallergenic aerated semi-occlusive dressing and a restraining bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no; no residual test substance was observed at removal of the dressing
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw, considering the density of 1.172 g/cm³ - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: clinical signs: frequently during the hours following application, and at least once a day thereafter for 14 days; mortality: frequently during the hours following application, and at least twice a day thereafter fro 14 days
- Frequency of weighing: day of administration (= day 1), days 8, 15
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No death occurred during the observation period.
- Clinical signs:
- No clinical signs and cutaneous reactions were observed during the study.
- Body weight:
- The body weight gain was not influenced by treatment.
- Gross pathology:
- Macroscopic examination of the main organs of the animals killed at the end of the study revealed no apparent abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 of TFMEA in rat (male/female) is >2000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study according to OECD guideline 402, adopted 24 February 1987, and EU method B.3, 31 July 1992, groups of app. 8 weeks old Sprague-Dawley ICO: OFA-SD rats (5/sex) were dermally exposed to TFMEA (99.94% a.i.) as supplied for 24 hours to ca 10% of the body surface area (5x6 cm (females), 5x7 cm (males)) at a single dose of 2000 mg/kg bw. Animals then were observed for 14 days.
No death occurred during the observation period. No clinical signs and cutaneous reactions were observed during the study. The body weight gain was not influenced by treatment. Macroscopic examination of the main organs of the animals killed at the end of the study revealed no apparent abnormalities.
Dermal LD50 combined > 2000 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
