Sodium 4-[[3-(acetylamino)phenyl]amino]-1-amino-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to microorganisms, other

Remarks:

growth inhibition P. fluorescens and E. coli

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

July 1977

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Qualifier:

no guideline available

Principles of method if other than guideline:

Not reported

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Pseudomonas fluorescens

Test type:

static

Water media type:

freshwater

Limit test:

yes

Nominal and measured concentrations:

10 g/L

Reference substance (positive control):

no

Duration:

3 h

Dose descriptor:

EC10

Effect conc.:

> 10 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Validity criteria fulfilled:

not applicable

Conclusions:

The 3h-ErC10 for P. fluorescens and E. coli were determined to be >10000 mg/L.

Reference 2

Endpoint:

activated sludge respiration inhibition testing

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

July 1977

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Qualifier:

no guideline available

Principles of method if other than guideline:

Not reported

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

activated sludge

Test type:

static

Water media type:

freshwater

Limit test:

yes

Nominal and measured concentrations:

100 mg/L

Reference substance (positive control):

no

Duration:

3 h

Dose descriptor:

IC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Validity criteria fulfilled:

not applicable

Conclusions:

The 3h-IC10 for activated sludge was determined to be >100 mg/L.

Reference 3

Endpoint:

activated sludge respiration inhibition testing

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

July 1982

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Qualifier:

no guideline available

Principles of method if other than guideline:

Not reported

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

activated sludge

Test type:

static

Water media type:

freshwater

Limit test:

yes

Nominal and measured concentrations:

100 mg/L

Reference substance (positive control):

no

Duration:

3 h

Dose descriptor:

IC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Validity criteria fulfilled:

not applicable

Conclusions:

The 3h-IC10 for activated sludge was determined to be >100 mg/L.

Reference 4

Endpoint:

activated sludge respiration inhibition testing

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

November 1982

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Qualifier:

no guideline available

Principles of method if other than guideline:

Not reported

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

activated sludge

Test type:

static

Water media type:

freshwater

Limit test:

yes

Nominal and measured concentrations:

100 mg/L

Reference substance (positive control):

no

Duration:

3 h

Dose descriptor:

IC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Validity criteria fulfilled:

not applicable

Conclusions:

The 3h-IC10 for activated sludge was determined to be >100 mg/L.

Reference 5

Endpoint:

activated sludge respiration inhibition testing

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

Mai 1983

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Qualifier:

no guideline available

Principles of method if other than guideline:

Not reported

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

activated sludge

Test type:

static

Water media type:

freshwater

Limit test:

yes

Nominal and measured concentrations:

100 mg/L

Reference substance (positive control):

no

Duration:

3 h

Dose descriptor:

IC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Validity criteria fulfilled:

not applicable

Conclusions:

The 3h-IC10 for activated sludge was determined to be >100 mg/L.

Description of key information

Based on a weight-of-evidence approach the IC50 (respiration inhibtion) to bacteria is >100 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:

100 mg/L