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Short-term toxicity to aquatic invertebrates

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Description of key information

48 hrs aquatic toxicity studies (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of3-Phenylpropyl acetate (122-72-5)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the3-Phenylpropyl acetate (122-72-5)wasestimated to be 55.789146423 mg/Lon the basis of intoxication at 20 degree C. As the3-Phenylpropyl acetate (122-72-5)considered being hazardous to aquatic invertebrates since the chemical was readily biodegradable and can be considered to be not classified as per the CLP regulations.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
55.789 mg/L

Additional information

Various predicted studies and read across study for 3-Phenylpropyl acetate(122-72-5)were reviewed to summarize the following information: 

48 hrs aquatic toxicity studies (SSS QSAR prediction model, 2016) were conducted to assess toxic effects of 3-Phenylpropyl acetate (122-72-5) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for 3-Phenylpropyl acetate (122-72-5)was estimated to be 55.789146423 mg/Lon the basis of intoxication at 20 degree C. As 3-Phenylpropyl acetate (122-72-5) can be considered being hazardous to aquatic invertebrates, but since the chemical was readily biodegradable, it can be considered to be not classified as per the CLP regulations.

48 hrs aquatic toxicity studies(EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of the3-Phenylpropyl acetate (122-72-5)and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for 3-Phenylpropyl acetate (122-72-5) was estimated to be 10.178mg/L. As the 3-Phenylpropyl acetate (122-72-5) considered being hazardous to aquatic invertebrates since the chemical was readily biodegradable and can be considered to be not classified as per the CLP regulations.

 

A short term toxicity to aquatic invertebrates study (Metsulfuron Methyl - Human Health and Ecological Risk Assessment– Final Report, 2005 ) on read across chemical Metsulfuron-methyl (74223-64-6) was performed in daphnia magna for 48 hrs in static test conditions in which no aeration given. The nominal concentrations used were 0, 5, 25, 50, 100, or 150 mg/l having 10 daphnids in each vessel with DMF used as a positive control. After the experiment, the no mortality was observed and EC 50 and NOEC value for Metsulfuron-methyl (74223-64-6) of short term toxicity to aquatic invertebrates was determined to be >150 mg/l and 150 mg/l.

From the above report for same read across chemical (Metsulfuron-methyl (74223-64-6)) another study of short term toxicity to aquatic invertebrates was performed in daphnia magna for 48 hrs in static test conditions. The nominal concentrations used were 0; NaOH control, 100, 130, 180, 240, 320, 420, 560, 750, or 1000mg/l having 10 daphnids in each vessel with NaoH was used as a positive control. In replicate exposure chambers, exposure to 750 mg/L caused 60% and 80% immobility after 48 hours, while exposure to 1000 mg/L caused 90% and 100% immobility. After the experiment, the EC 50 and NOEC value for Metsulfuron-methyl (74223-64-6) of short term toxicity to aquatic invertebrates was determined to be 720 mg/l and 420 mg/l. Based on the result, Metsulfuron-methyl (74223-64-6) was considered to be not hazardous to aquatic invertebrates and can be considered to be not classified chemical as per the CLP regulations.

One more read across chemical name benzyl bromoacetate (5437-45-6) was studied in daphnia magna for 48 hr at concentration from 0.23- 0.25 mg/l. From the study the EC 50 value was determined to be 0.23 mg/L on the basis of intoxication effect resulting in immobility. As the chemical was considered to be toxic to aquatic invertebrates but as the substance is readily biodegradable, so it can be considered that the benzyl bromoacetate (5437-45-6) can be considered to be not classified to aquatic invertebrates as per the CLP regulations.

Based on the above prediction values and read across chemical Metsulfuron-methyl (74223-64-6) and benzyl bromoacetate (5437-45-6) studies, it can be concluded that the 3-Phenylpropyl acetate (122-72-5) was considered to be hazardous to aquatic invertebrates but as the substance is readily biodegradable and result of read across chemical also suggested that the 3-Phenylpropyl acetate (122-72-5) can be considered to be not classified to aquatic invertebrates as per the CLP regulations.