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EC number: 204-569-8 | CAS number: 122-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates β in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
3- Phenylpropyl acetate is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is frompeer-reviewed journal
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study was conducted on rats for the test compound 3- Phenylpropyl acetate
- GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 2220, 3330, 5000 and 7000 mg/Kg
- No. of animals per sex per dose:
- Total: 40 2220 mg/kg :10 rats3330 mg/kg :10 rats5000 mg/kg :10 rats7000 mg/kg :10 rats
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: clinical signs and mortality
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 840 - 5 560
- Remarks on result:
- other: No effect on survival and clinical sign
- Mortality:
- 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing
- Clinical signs:
- other: When treated with 3330 and 7000 mg/kg, piloerection were observed in treated rats. When treated with 5000 and 7000 mg/kg,depression and a negative righting reflex were observed in treated rats.
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
- Executive summary:
In a acute oral toxicity study, group of 10 rats were treated with 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
Reference
Dose (mg/Kg) | Mortality |
2220 | 0 |
3330 | 2 |
5000 | 6 |
7000 | 9 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 700 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer-revieed journal
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed journal
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute dermal toxicity study was conducted on rabbits to evaluate toxic nature of 3- Phenylpropyl acetate.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- other: dermally
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/Kg
- No. of animals per sex per dose:
- 10 rabbits
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: Mortality and clinical sign were observed.
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No effect on survival and clinical sign
- Mortality:
- When treated wtih 5000 mg/kg bw, 1 rabbit were died.
- Clinical signs:
- other: No clinical signs of toxicity were observed in treated rabbits.
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
- Executive summary:
In a acute dermal toxicity study, group of 10 rabbits were treated with 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer-revieed journal
Additional information
Acute oral toxicity:
Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) for acute oral toxicity is summarized below
In a study given by McGintyet al(2012) and Morenoet al(1979), acute oral toxicity was evaluated in group of 10 rats by using 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
In a study given by Belsitoet al(2012), acute oral toxicity was evaluated in 10 rats by using 3- Phenylpropyl acetate in the concentration of 4700 orally. 50 % mortality was observed at 4700 mg/kg bw.. Therefore, LD50 was considered to be 4700 mg/kg (3800-5600) when rats were treated with 3- Phenylpropyl acetate orally.
Thus, Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) is likely to be non hazardous by oral route of exposure in rats.
Acute dermal toxicity:
Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and itβs 80-90% similar read across benzyl acetate (CAS no 144-11-4) for acute dermal toxicity is summarized below
In a study given by McGintyet al(2012), acute dermal toxicity was evaluated in group of 10 rabbits by using 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
In a study given by Morenoet al(1979), acute dermal toxicity was evaluated in group of rabbits by using Phenylpropyl acetate in the concentration of 5000 mg/Kg orally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Phenylpropyl acetate dermally.
In a study given by McGintyet al(2012), acute dermal toxicity was evaluated rabbits treated with benzyl acetate in the concentration of 5000 mg/kg bw dermally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with benzyl acetate topically.
Thus, Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and its 80-90% similar read across benzyl acetate (CAS no 144-11-4) is likely to be non hazardous by dermal route of exposure in rabbits.
Justification for selection of acute toxicity β oral endpoint
LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
Justification for selection of acute toxicity β dermal endpoint
LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
Justification for classification or non-classification
Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and its 80-90% similar read across benzyl acetate (CAS no 144-11-4) is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.
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