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Description of key information

3- Phenylpropyl acetate is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is frompeer-reviewed journal
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Acute oral toxicity study was conducted on rats for the test compound 3- Phenylpropyl acetate
GLP compliance:
no
Test type:
other: No data
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
2220, 3330, 5000 and 7000 mg/Kg
No. of animals per sex per dose:
Total: 40 2220 mg/kg :10 rats3330 mg/kg :10 rats5000 mg/kg :10 rats7000 mg/kg :10 rats
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: clinical signs and mortality
Statistics:
No data available
Preliminary study:
No data available
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 700 mg/kg bw
Based on:
test mat.
95% CL:
3 840 - 5 560
Remarks on result:
other: No effect on survival and clinical sign
Mortality:
9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing
Clinical signs:
other: When treated with 3330 and 7000 mg/kg, piloerection were observed in treated rats. When treated with 5000 and 7000 mg/kg,depression and a negative righting reflex were observed in treated rats.
Gross pathology:
No data available
Other findings:
No data available

Dose (mg/Kg)

Mortality

2220

0

3330

2

5000

6

7000

9
Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.
Executive summary:

In a acute oral toxicity study, group of 10 rats were treated with 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
4 700 mg/kg bw
Quality of whole database:
Data is Klimisch 2 and from peer-revieed journal

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer-reviewed journal
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Acute dermal toxicity study was conducted on rabbits to evaluate toxic nature of 3- Phenylpropyl acetate.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes
Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available
Type of coverage:
other: dermally
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/Kg
No. of animals per sex per dose:
10 rabbits
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: Mortality and clinical sign were observed.
Statistics:
No data available
Preliminary study:
No data available
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No effect on survival and clinical sign
Mortality:
When treated wtih 5000 mg/kg bw, 1 rabbit were died.
Clinical signs:
other: No clinical signs of toxicity were observed in treated rabbits.
Gross pathology:
No data available
Other findings:
No data available
Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
Executive summary:

In a acute dermal toxicity study, group of 10 rabbits were treated with 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw
Quality of whole database:
Data is Klimisch 2 and from peer-revieed journal

Additional information

Acute oral toxicity:

Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) for acute oral toxicity is summarized below

In a study given by McGintyet al(2012) and Morenoet al(1979), acute oral toxicity was evaluated in group of 10 rats by using 3- Phenylpropyl acetate in the concentration of 2220, 3330, 5000 and 7000 mg/Kg orally and observed for 14 days. 9 rats were died at 7000 mg/kg, 6 at 5000 mg/kg, 2 at 3330 mg/kg and no mortality was observed at 2220 mg/kg bw. All deaths occurred within 2 days after dosing. Piloerection were observed at 3330 and 7000 mg/kg and depression and a negative righting reflex at 5000 and 7000 mg/kg in treated rats. Therefore, LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.

In a study given by Belsitoet al(2012), acute oral toxicity was evaluated in 10 rats by using 3- Phenylpropyl acetate in the concentration of 4700 orally. 50 % mortality was observed at 4700 mg/kg bw.. Therefore, LD50 was considered to be 4700 mg/kg (3800-5600) when rats were treated with 3- Phenylpropyl acetate orally.

Thus, Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) is likely to be non hazardous by oral route of exposure in rats.

Acute dermal toxicity:

Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and it’s 80-90% similar read across benzyl acetate (CAS no 144-11-4) for acute dermal toxicity is summarized below

In a study given by McGintyet al(2012), acute dermal toxicity was evaluated in group of 10 rabbits by using 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.

In a study given by Morenoet al(1979), acute dermal toxicity was evaluated in group of rabbits by using Phenylpropyl acetate in the concentration of 5000 mg/Kg orally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Phenylpropyl acetate dermally.

In a study given by McGintyet al(2012), acute dermal toxicity was evaluated rabbits treated with benzyl acetate in the concentration of 5000 mg/kg bw dermally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with benzyl acetate topically.

Thus, Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and its 80-90% similar read across benzyl acetate (CAS no 144-11-4) is likely to be non hazardous by dermal route of exposure in rabbits.

Justification for selection of acute toxicity – oral endpoint

LD50 was considered to be 4700 mg/kg (3840-5560) when rats were treated with 3- Phenylpropyl acetate orally.

Justification for selection of acute toxicity – dermal endpoint

LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.

Justification for classification or non-classification

Based on the data available for target 3- Phenylpropyl acetate (CAS no 122-72-5) and its 80-90% similar read across benzyl acetate (CAS no 144-11-4) is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.