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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance material review on 3-phenylpropyl acetate
Author:
D. McGinty, C.S. Letizia, A.M. Api
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S457–S461
Reference Type:
publication
Title:
: A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients
Author:
D. Belsito a, D. Bickers a, M. Bruze b, P. Calow c, M.L. Dagli d, A.D. Fryer e, H. Greim f, Y. Miyachi g, J.H. Saurat h, I.G. Sipes
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S269–S313

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Acute dermal toxicity study was conducted on rabbits to evaluate toxic nature of 3- Phenylpropyl acetate.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-phenylpropyl acetate
EC Number:
204-569-8
EC Name:
3-phenylpropyl acetate
Cas Number:
122-72-5
Molecular formula:
C11H14O2
IUPAC Name:
3-phenylpropyl acetate
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report):3- Phenylpropyl acetate- Molecular formula (if other than submission substance):C11H14O2- Molecular weight (if other than submission substance):178.23 g/mole- Substance type:Organic- Physical state:Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: dermally
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
5000 mg/Kg
No. of animals per sex per dose:
10 rabbits
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: Mortality and clinical sign were observed.
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No effect on survival and clinical sign
Mortality:
When treated wtih 5000 mg/kg bw, 1 rabbit were died.
Clinical signs:
No clinical signs of toxicity were observed in treated rabbits.
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
Executive summary:

In a acute dermal toxicity study, group of 10 rabbits were treated with 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.