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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from publication

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs: PHENYLPROPYL ACETATE
Author:
D.L.J. Opdyke
Year:
1974
Bibliographic source:
Food and Cosmetics Toxicology Volume 12, Issues 7–8, December 1974, Pages 965-966
Reference Type:
publication
Title:
A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients
Author:
The RIFM Expert Panel - D. Belsito, D. Bickers, M. Bruze, P. Calow, M.L. Dagli, A.D. Fryer,H. Greim, Y. Miyachi, J.H. Saurat, I.G. Sipes
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S269–S313
Reference Type:
publication
Title:
Fragrance material review on 3-phenylpropyl acetate
Author:
D. McGinty, C.S. Letizia, A.M. Api
Year:
2012
Bibliographic source:
Food and Chemical Toxicology 50 (2012) S457–S461

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
Skin irritation study was conducted on the human subjects to evaluate the irritating potential of 3- Phenylpropyl acetate
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
3- Phenylpropyl acetate
IUPAC Name:
3- Phenylpropyl acetate
Constituent 2
Chemical structure
Reference substance name:
3-phenylpropyl acetate
EC Number:
204-569-8
EC Name:
3-phenylpropyl acetate
Cas Number:
122-72-5
Molecular formula:
C11H14O2
IUPAC Name:
3-phenylpropyl acetate
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): 3- Phenylpropyl acetate- Molecular formula: C11H14O2- Molecular weight: 178.23 g/mol- Substance type: Organic- Physical state: Liquid- Smiles: c1(CCCOC(C)=O)ccccc1-InChI: 1S/C11H14O2/c1-10(12)13-9-5-8-11-6-3-2-4-7-11/h2-4,6-7H,5,8-9H2,1H3

Test animals

Species:
human
Strain:
other: not applicable
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
8%
Duration of treatment / exposure:
48 hours
Observation period:
48 hours after application
Number of animals:
5 adult patients
Details on study design:
In preliminary study to a maximization test, an 8% concentration of 3-phenylpropyl acetate was applied under occlusion for48 h to five adult patients.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 48 hours
Reversibility:
no data
Remarks on result:
other: Non-irritating
Irritant / corrosive response data:
none of the adult patient showed skin irritation effects.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
The test chemical 3- Phenylpropyl acetate (CAS No: 122-72-5) was considered to be non-irritating to the skin of 5 adult human patients.
Executive summary:

Skin irritation study was conducted on 5 adult human patients to evaluate the irritating potential of the 3- Phenylpropyl acetate (CAS No: 122-72-5)as a preliminary study to a maximization test,.

 

The test material was tested at 8% in petrolatum for 48 hours as a closed patch and observations were made.

 

On the basis of observations made, 3-Phenylpropyl acetate (CAS No: 122-72-5) was considered as non-irritating to the skin of humans.