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Physical & Chemical properties

Water solubility

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Administrative data

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
ca. 352 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 7
Conclusions:
The water solubility of the test item was determined to be 352 g/l (-/+ 7 g/l) at 20 °C using the flask method (OECD 105) for the performance of the main test.
Executive summary:

The water solubility of the test item was determined to be 352 g/l (-/+ 7 g/l) at 20 °C using the flask method (OECD 105) for the performance of the main test.

Description of key information

The water solubility of the test item was determined to be 352 g/l (-/+ 7 g/l) at 20 °C using the flask method (OECD 105) for the performance of the main test.

Key value for chemical safety assessment

Water solubility:
352 g/L
at the temperature of:
20 °C

Additional information

The water solubility was determined according to OECD 105 and Regulation (EC) No 440/2008 method A.6 using the flask method with HPLC analysis.

The quantity of test item necessary to saturate the desired volume of water is estimated from the preliminary iest. About five times that quantity is weighed into each of three glass vessels fitted with glass

stoppers and the chosen volume of water is added to each vessel. The batches are stirred for different times at 30 °C (24 h experiment, 48 h experiment, 72 h experiment) in tightly closed flasks. Another

experiment is performed according to this procedure but without test item ("blank"). After equilibration (further stirring for 24 h at 20 °C) the suspensions are taken and prepared for the analytical determination. The pH values of the saturated solutions are determined.

The water solubility of the test item was determined to be 352 g/l (+/- 7 g/l) at 20 °C.

About 27.75 g test item were weighed into stoppered Erlenmeyer flasks (nine parallels) according to the estimated solubility based on the Preliminary Test. After the addition of 10 mL ultrapure water, the flasks were agitated at 30 °C. After one day, three of the vessels were removed and re-equilibrated at 20 °C for 24 hours. The content of the

vessel was then centrifuged at 20 °C and the concentration in the clear aqueous phase was determined by HPLC. The other flasks were treated similarly after initial equilibration at 30 °C for two and three

days, respectively. The samples were diluted before the analysis (two parallel dilutions). The pH of each sample was recorded. The water solubility of the test substance was determined to be 631.68 ± 6.32

g/L (95 % confidence interval) at 20 °C ± 1 °C